ArticleNPJ microgravity2020
Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight.
Article in NPJ microgravity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long-duration spaceflight.Experimental physiology · 2026Article
- Optic nerve sheath diameter increases during 12Frontiers in physiology · 2026Article
- MReye-Seg: development and validation of an automated MRI pipeline for standardised ocular and orbital morphometrics.Eye (London, England) · 2025Article
- Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): a systematic review.NPJ microgravity · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- The Effects of Antioxidant Cocktail on Ophthalmological Changes Induced by a 60-Day Head-Down Bed Rest in a Randomized Trial.Life (Basel, Switzerland) · 2024Article
- Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest.NPJ microgravity · 2024Article
- Impact of Microgravity and Other Spaceflight Factors on Retina of Vertebrates and Humans In Vivo and In Vitro.Life (Basel, Switzerland) · 2023Review
- Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension.Investigative ophthalmology & visual science · 2023Article
- Optic nerve sheath diameter and spaceflight: defining shortcomings and future directions.NPJ microgravity · 2022Review
- The glymphatic pathway in the optic nerve: did astronauts already reveal signs of its existence?NPJ microgravity · 2021Article
- MRI-based quantification of ophthalmic changes in healthy volunteers during acute 15° head-down tilt as an analogue to microgravity.Journal of the Royal Society, Interface · 2021Article
- Effects of Venoconstrictive Thigh Cuffs on Dry Immersion-Induced Ophthalmological Changes.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
A subset of long-duration spaceflight astronauts have experienced ophthalmic abnormalities, collectively termed spaceflight-associated neuro-ocular syndrome (SANS). Little is understood about the pathophysiology of SANS; however, microgravity-induced alterations in intracranial pressure (ICP) due to headward fluid shifts is the primary hypothesized contributor. In particular, potential changes in optic nerve (ON) tortuosity and ON sheath (ONS) distension may indicate altered cerebrospinal fluid dynamics during weightlessness. The present longitudinal study aims to provide a quantitative analysis of ON and ONS cross-sectional areas, and ON deviation, an indication of tortuosity, before and after spaceflight. Ten astronauts undergoing ~6-month missions on the International Space Station (ISS) underwent high-resolution magnetic resonance imaging (MRI) preflight and at five recovery time points extending to 1 year after return from the ISS. The mean changes in ON deviation, ON cross-sectional area, and ONS cross-sectional area immediately post flight were -0.14 mm (95% CI: -0.36 to 0.08, Bonferroni-adjusted
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.