ArticleNPJ microgravity2020
Cardiovascular deconditioning during long-term spaceflight through multiscale modeling.
Article in NPJ microgravity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06633692 (Female Pelvic Blood Flow Under Simulated Microgravity), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Female Pelvic Blood Flow Under Simulated Microgravity
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- Spaceflight and sport science: Physiological monitoring and countermeasures for the astronaut-athlete on Mars exploration missions.Experimental physiology · 2026Review
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- AI-based prediction of VONPJ microgravity · 2025Article
- Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight.Investigative ophthalmology & visual science · 2025Article
- Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025Review
- Walking-induced inertial effects on the cardiovascular system.Frontiers in network physiology · 2025Article
- Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System.International journal of molecular sciences · 2024Review
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight.Nature reviews. Cardiology · 2024Review
- Numerical analysis of blood flow in the abdominal aorta under simulated weightlessness and earth conditions.Scientific reports · 2024Article
- Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity.Signal transduction and targeted therapy · 2024Article
- Spaceflight effects on human vascular smooth muscle cell phenotype and function.NPJ microgravity · 2024Article
- Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.NPJ microgravity · 2024Article
- Modelling large scale artery haemodynamics from the heart to the eye in response to simulated microgravity.NPJ microgravity · 2024Article
- Cardiovascular responses to leg-press exercises during head-down tilt.Frontiers in sports and active living · 2024Article
- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Bone marrow adiposity modulation after long duration spaceflight in astronauts.Nature communications · 2023Article
- Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.American journal of physiology. Heart and circulatory physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology, and push scientific boundaries further. A key area of importance is cardiovascular deconditioning, that is, the collection of hemodynamic changes-from blood volume shift and reduction to altered cardiac function-induced by sustained presence in microgravity. A thorough grasp of the 0G adjustment point per se is important from a physiological viewpoint and fundamental for astronauts' safety and physical capability on long spaceflights. However, hemodynamic details of cardiovascular deconditioning are incomplete, inconsistent, and poorly measured to date; thus a computational approach can be quite valuable. We present a validated 1D-0D multiscale model to study the cardiovascular response to long-term 0G spaceflight in comparison to the 1G supine reference condition. Cardiac work, oxygen consumption, and contractility indexes, as well as central mean and pulse pressures were reduced, augmenting the cardiac deconditioning scenario. Exercise tolerance of a spaceflight traveler was found to be comparable to an untrained person with a sedentary lifestyle. At the capillary-venous level significant waveform alterations were observed which can modify the regular perfusion and average nutrient supply at the cellular level. The present study suggests special attention should be paid to future long spaceflights which demand prompt physical capacity at the time of restoration of partial gravity (e.g., Moon/Mars landing). Since spaceflight deconditioning has features similar to accelerated aging understanding deconditioning mechanisms in microgravity are also relevant to the understanding of aging physiology on the Earth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.