Evidence map›Paper›PMID 33083513›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2020

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.

Stacie Weninger, Bjorn Sperling, Robert Alexander, Magnus Ivarsson, Fiona M Menzies, Peter Powchik, Christopher J Weber, C Anthony Altar, Ronald G Crystal, Stephen J Haggarty and 3 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Dementia in Africa: Current evidence, knowledge gaps, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 3 countries.

Stacie WeningerFBRI Cambridge Massachusetts USA.
Bjorn SperlingH. Lundbeck A/S Copenhagen Denmark.
Robert AlexanderTakeda Pharmaceuticals International Co. Cambridge Massachusetts USA.
Magnus IvarssonRodin Therapeutics 300 Technology Square Cambridge Massachusetts USA.
Fiona M MenziesEli Lilly and Co, Erl Wood Manor Windlesham UK.
Peter PowchikUnited Neuroscience 9 Exchange Place, I. F. S. C Dublin Ireland.
Christopher J WeberAlzheimer's Association Chicago Illinois USA.
C Anthony AltarSplice Therapeutics Bethesda Maryland USA.
Ronald G CrystalDepartment of Genetic Medicine Weill Cornell Medicine New York New York USA.
Stephen J HaggartyChemical Neurobiology Laboratory Center for Genomic Medicine Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Jeanne LoringScripps Research Institute La Jolla California USA.
Lisa J BainIndependent Science Writer Elverson Pennsylvania USA.
Maria C CarrilloAlzheimer's Association Chicago Illinois USA.
Alzheimer's Association · USCenter for Systems Biology · USCornell University · USEli Lilly (United Kingdom) · GBLundbeck (Denmark) · DKRodin Therapeutics (United States) · USScripps Research Institute · UST1D Exchange · USTakeda (United States) · USUnited Therapeutics (United States) · US

Funding

Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal DementiR01NS108115 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HAGGARTY, STEPHEN J, HERZ, JOACHIM J · 2018 to 2022
$4.0M
NINDS NIH HHS R01 NS108115
6 · The paper itself

Abstract

As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earliest biological processes of AD/dementia would help inform drug target selection. Currently there are a number of programs exploring these alternate avenues. This meeting will allow experts in the field (academia, industry, government) to provide perspectives and experiences that can help elucidate what the pipeline looks like today and what avenues hold promise in developing new therapies across the stages of AD. The focus here is on Active Immunotherapies and Alternative Therapeutic Modalities. This topic includes active vaccines, antisense oligomers, and cell-based therapy among others, and highlights new clinical developments that utilize these modalities.

Identifiers

PMID33083513
PMCPMC7550557
OpenAlexW3092947909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.