ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis.Alzheimer's research & therapy · 2025Pooled it
- Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning.Brain imaging and behavior · 2024Pooled it
- Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.Nature communications · 2026Article
- Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases.Journal of advanced research · 2026Article
- Regional growth rates of white matter hyperintensities are associated with beta-amyloid burden.Neurobiology of aging · 2026Article
- Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.GeroScience · 2026Article
- Age-inappropriate white matter injury reveals hidden cerebral small vessel disease burden and mortality risk.Cerebral circulation - cognition and behavior · 2026Article
- Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer's disease.medRxiv : the preprint server for health sciences · 2025Article
- White matter hyperintensity modulates the amyloid-tau-cognition association and anti-amyloid treatment efficacy in asymptomatic older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain.European journal of nuclear medicine and molecular imaging · 2025Article
- White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex differences in vulnerability to tau pathology: Impact on cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.NeuroImage · 2025Article
- White matter fractional anisotropy decreases precede hyperintensities in Alzheimer's disease.Cell reports. Medicine · 2025Article
- Spatial-temporal interactions between white matter hyperintensities and multiple pathologies across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- White Matter Hyperintensities and Microstructural Alterations in Contact Sport Athletes from Adolescence to Early Midlife.Journal of neurotrauma · 2024Article
- Beyond Hypertension: Examining Variable Blood Pressure's Role in Cognition and Brain Structure.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Irregular word reading as a marker of semantic decline in Alzheimer's disease: implications for premorbid intellectual ability measurement.Alzheimer's research & therapy · 2024Article
- Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis.European journal of epidemiology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionCognitive decline in Alzheimer's disease is associated with amyloid beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the temporal relationships among these factors is not well established.
methodsData included white matter hyperintensity (WMH) load, gray matter (GM) atrophy and Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (Aβ1-42) for 461 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear regressions were used to assess the relationships among baseline WMH, GM, and Aβ1-42 to changes in WMH, GM, Aβ1-42, and cognition at 1-year follow-up.
resultsBaseline WMHs and Aβ1-42 predicted WMH increase and GM atrophy. Baseline WMHs and Aβ1-42 predicted worsening cognition. Only baseline Aβ1-42 predicted change in Aβ1-42. DISCUSSION: Baseline WMHs lead to greater future GM atrophy and cognitive decline, suggesting that WM damage precedes neurodegeneration and cognitive decline. Baseline Aβ1-42 predicted WMH increase, suggesting a potential role of amyloid in WM damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.