Evidence map›Paper›PMID 33083468›Full record

ArticleBioMed research international2020

Effect of Dexmedetomidine on Postoperative Lung Injury during One-Lung Ventilation in Thoracoscopic Surgery.

Jun Meng, Qin Lv, Jiaxiang Yao, Siyu Wang, Kun Yang

Retracted Registry-linked trialOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT04932746 (The Effect of Dexmedetomidine on Oxygen and Intrapulmonary Shunt During One Lung Ventilation in Pediatric Surgery), which is not on this map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04932746 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Dexmedetomidine on Oxygen and Intrapulmonary Shunt During One Lung Ventilation in Pediatric Surgery: Randomized Controlled Trial

TypeinterventionalSponsorDamascus UniversityRan2021 to 2023Enrolled110ConditionsOne Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, PneumonectomyArmsDexmedetomidine, Placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jun MengDepartment of Cardiovascular Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Qin LvDepartment of Anaesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Jiaxiang YaoDepartment of Anaesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Siyu WangDepartment of Anaesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Kun YangDepartment of Anaesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.ORCID https://orcid.org/0000-0003-3607-336X
Kunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of dexmedetomidine on postoperative lung injury in patients undergoing thoracoscopic surgery.

methodsFrom March 2019 to October 2019, 40 patients were randomly divided into two groups: dexmedetomidine group (group D) and control group (group C). Except recording the general condition of the patients in both groups preoperatively and intraoperatively, the oxygenation index (OI) and alveolar-arterial oxygen partial pressure difference (A-aDO

resultsThere was no significant difference in the general condition before and during operation between the two groups. There was no significant difference in arterial blood IL-8 content between the two groups at the T0 time point, but the arterial blood IL-8 content at the T2 time point was significantly higher than that at the T0 time point, especially in group C. The results of immunohistochemistry and Western blot showed that the expression level of AQP1 protein in the isolated lung tissue of group D was significantly higher than that of group C (

conclusionDexmedetomidine can reduce the level of plasma IL-8 and upregulate the expression of AQP1 in the lung tissue of patients undergoing thoracoscopic surgery under one-lung ventilation, but it has no significant effect on the incidence of postoperative PPCs. Dexmedetomidine can be safely used in thoracoscopic surgery and has a certain protective effect on lung injury.

Indexed as

Blood Gas AnalysisDexmedetomidineFemaleHumansLungLung InjuryMaleMiddle AgedOne-Lung VentilationPostoperative ComplicationsPostoperative PeriodThoracoscopyDexmedetomidine

Identifiers

PMID33083468
PMCPMC7557917
OpenAlexW3092572370

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.