Evidence map›Paper›PMID 33083220›Full record

ArticleRespiratory medicine case reports2020

Good response with durvalumab after chemoradiotherapy for epidermal growth factor receptor exon 20 insertion adenocarcinoma: A case report.

Shun Matsuura, Keisuke Morikawa, Yutaro Ito, Namio Kagoo, Tsutomu Kubota, Koshiro Ichijo, Eisuke Mochizuki, Masahiro Uehara, Masanori Harada, Masaru Tsukui and 1 more

Abstract readCase Reports
In one paragraph

Article in Respiratory medicine case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shun MatsuuraDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Keisuke MorikawaDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Yutaro ItoDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Namio KagooDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Tsutomu KubotaDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Koshiro IchijoDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Eisuke MochizukiDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Masahiro UeharaDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Masanori HaradaDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Masaru TsukuiDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.
Naoki KoshimizuDivision of Respiratory Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) exon 20 insertion is not associated with sensitivity to EGFR tyrosine kinase inhibitors and chemotherapy. Here, we report the case of a 41-year-old man who presented a right lower lobe nodule and mediastinal lymph node enlargement diagnosed as EGFR exon 20 insertion adenocarcinoma with high-expression programmed cell death ligand 1 (PD-L1). He showed stable disease to chemoradiation treatment at the primary tumor site. However, durvalumab treatment has good response. Non-small cell lung cancer with EGFR exon 20 insertion and high PD-L1 expression may be treated with immunotherapy exposure.

Indexed as

DurvalumabEGFRExon 20 insertionNon-small-cell lung cancer

Identifiers

PMID33083220
PMCPMC7552097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.