Evidence map›Paper›PMID 33083206›Full record

ArticlePreventive medicine reports2020

Prenatal smoking and the risk of early childhood caries: A prospective cohort study.

Aderonke A Akinkugbe, Tegwyn H Brickhouse, Marcelle M Nascimento, Gary D Slade

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Preventive medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Passive Smoking and Oral Health of Infants, Preschoolers, and Children: A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Aderonke A AkinkugbeDepartment of Dental Public Health and Policy, School of Dentistry, Virginia Commonwealth University, Richmond, VA, United States.
Tegwyn H BrickhouseDepartment of Dental Public Health and Policy, School of Dentistry, Virginia Commonwealth University, Richmond, VA, United States.
Marcelle M NascimentoDepartment of Restorative Dental Sciences, University of Florida College of Dentistry, Gainesville, FL, United States.
Gary D SladeDepartment of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Virginia Commonwealth University · USUniversity of Florida · USUniversity of North Carolina at Chapel Hill · US

Funding

Are prenatal smoking and pregnancy BMI risk factors for caries experience in the offspring?R03DE028403 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKINKUGBE, ADERONKE ARAMIDE · 2019 to 2020
$310k
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009NIDCR NIH HHS L40 DE028120NIDCR NIH HHS R03 DE028403Wellcome Trust
6 · The paper itself

Abstract

introductionDental caries is a chronic complex disease of multifactorial etiology that affects a quarter of U.S. children. This study evaluated the association between prenatal smoking and offspring caries experience and used a negative control exposure analysis to assess if the association is causal.

methodsData from 1429 mother-offspring participants of the 1991/92 Avon Longitudinal Study of Parents and Children conducted in Bristol, England were analyzed. Prenatal smoking (yes v. no) and quantity smoked (none, <half pack, ≥half pack) were self-reported while offspring caries experience was determined by clinical oral examinations at 3 time points. Discrete time hazards regression estimated hazard odds of first occurrence of offspring caries, and substituted partner smoking for prenatal smoking in a negative control exposure analysis.

resultsOverall, 22% smoked during pregnancy while 36% of partners smoked. The adjusted hazard odds of first occurrence of caries experience in the offsprings of prenatal smokers compared to the offsprings of non-smokers was 1.42 (95% CI: 1.08, 1.86). Relative to non-smoking, smoking <half pack/day and ≥half pack/day during pregnancy were associated with higher adjusted hazard odds of offspring caries experience: 1.10 (95% CI: 0.79, 1.54) and 1.38 (0.98, 1.95) respectively. Partner smoking was associated with 33% (95% CI: 1.07, 1.65) higher adjusted hazard odds of first offspring caries experience occurrence.

conclusionsPrenatal and partner smoking appear associated with greater offspring caries experience. The positive association with partner smoking suggests either a shared genetic predisposition or unmeasured common environmental factors with the mother as opposed to a direct biological effect of the intrauterine environment.

Indexed as

ALSPACDental CariesEpidemiologic studyPregnancyRisk factorsSmoking

Identifiers

PMID33083206
PMCPMC7554205
OpenAlexW3087866503

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.