Evidence map›Paper›PMID 33082996›Full record

ArticleObesity science & practice2020

Urine dipsticks are not accurate for detecting mild ketosis during a severely energy restricted diet.

Alice A Gibson, Elif I Eroglu, Kieron Rooney, Claudia Harper, Sally McClintock, Janet Franklin, Tania P Markovic, Radhika V Seimon, Amanda Sainsbury

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity science & practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alice A GibsonBoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia.ORCID https://orcid.org/0000-0001-8750-9720
Elif I ErogluBoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia.
Kieron RooneyDiscipline of Exercise and Sport Science, Faculty of Medicine and Health, Charles Perkins Centre University of Sydney Sydney New South Wales Australia.ORCID https://orcid.org/0000-0001-6563-7617
Claudia HarperBoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia.ORCID https://orcid.org/0000-0001-7444-1886
Sally McClintockBoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia.
Janet FranklinMetabolism & Obesity Services Royal Prince Alfred Hospital Camperdown New South Wales Australia.ORCID https://orcid.org/0000-0002-0885-5906
Tania P MarkovicBoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia.
Radhika V SeimonBoden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Faculty of Medicine and Health The University of Sydney Camperdown New South Wales Australia.ORCID https://orcid.org/0000-0002-3903-4801
Amanda SainsburySchool of Human Sciences, Faculty of Science The University of Western Australia Crawley Western Australia Australia.ORCID https://orcid.org/0000-0001-9176-1574
The University of Sydney · AURoyal Prince Alfred Hospital · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetection of the mild ketosis induced by severely energy-restricted diets may be a clinically useful way to monitor and promote dietary adherence. Mild ketosis is often assessed using urine dipsticks, but accuracy for this purpose has not been tested.

objectiveTo determine the accuracy of urine dipsticks to detect mild ketosis during adherence to a severely energy-restricted diet.

methodsTwo hundred and sixty three (263) fasting urine and 263 fasting blood samples were taken from 50 women (mean [standard deviation, SD] age 58.0 [4.3] years and body mass index 34.3 [2.4] kg/m

resultsAt threshold blood β-hydroxybutyrate concentrations of ≥0.3mM, ≥0.5mM and ≥1.0mM, the sensitivity of the urine dipsticks was 35%, 52% and 76%; the specificity was 100%, 97% and 78%; and the area under the receiver operating characteristic curves was 0.67, 0.74 and 0.77, respectively. These low levels of sensitivity mean that 65%, 48% or 24% of the instances when a person was in ketosis were not detected by the urine dipsticks.

conclusionUrine dipsticks are not an accurate or clinically useful means of detecting mild ketosis in people undergoing a severely energy-restricted diet and should thus not be recommended in clinical treatment protocols. If monitoring of mild ketosis is indicated (eg, to monitor or help promote adherence to a severely energy-restricted diet), then blood monitors should be used instead.

Indexed as

ketogenic dietmeal replacementvery low calorie dietvery low energy diet

Identifiers

PMID33082996
PMCPMC7556427
OpenAlexW3031708188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.