ArticleJournal of conservative dentistry : JCD
Histological evaluation of pulpal response to direct pulp capping using statins with α-tricalcium phosphate and mineral trioxide aggregate in human teeth.
Article in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Effect of Simvastatin on Success of Pulpotomy in Carious Permanent Molars With Symptomatic Irreversible Pulpitis: A Randomised Controlled Trial.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Trial
- Harnessing and Optimizing α-TCP for Oral Tissue Engineering and Regenerative Dentistry.International dental journal · 2026Review
- Genetic reduction or deletion of osteopontin in osteomalacicJBMR plus · 2025Article
- Histological evaluation of keratin and keratin with tricalcium phosphate as pulp capping agents: An animal study.Journal of conservative dentistry and endodontics · 2025Article
- The Effect of Simvastatin on Odontoblastic Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study.Dentistry journal · 2025Article
- Comparative evaluation of transforming growth factor-beta 1 release from dentin matrix with double antibiotic paste, probiotics, and simvastatin as intracanal medicaments: AnJournal of conservative dentistry and endodontics · 2025Article
- Comparative evaluation of cytotoxic effects of a new biomaterial nanohydroxyapatite-lactoferrin, nanohydroxyapatite, mineral trioxide aggregate, and calcium-enriched mixture on human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2025Article
- Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review.Materials (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to compare the outcome of direct pulp capping by statins with α-tricalcium phosphate (α-TCP) and mineral trioxide aggregate (MTA) on pulp tissue of human teeth through histological evaluation.
aimsThe aim of the present study is to compare the pulpal response of statins (simvastatin or atorvastatin) with α-TCP to that of MTA on human teeth by light microscopic histological evaluation. MATERIALS AND
methodsNinety intact premolar teeth scheduled for orthodontic extraction were used for the study. Class 1 cavities were prepared, and the pulp was mechanically exposed under rubber dam isolation. The samples were divided into three groups of thirty teeth each (Group I - simvastatin + α-TCP, Group II - atorvastatin + α-TCP, and Group III - MTA), and the test materials were placed accordingly. After the experimental periods of 7, 30, and 90 days, the teeth were extracted atraumatically. The samples were then evaluated for the degree of inflammation, tissue damage, and hard tissue formation under light microscope, and they were scored based on the histopathologic findings. STATISTICAL ANALYSIS: The results were analyzed statistically using the Chi-square test.
resultsThere was no statistically significant difference between Groups I, II, and III in terms of inflammation, tissue damage, and hard tissue formation for all the three observation periods (
conclusionsSimvastatin and atorvastatin with α-TCP were found to be effective in inducing dentin bridge formation which was comparable to MTA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.