Evidence map›Paper›PMID 33082495›Full record

ArticleScientific reports2020

Differences in maternal gene expression in Cesarean section delivery compared with vaginal delivery.

Prachi Kothiyal, Keriann Schulkers, Xinyue Liu, Sahel Hazrati, Thierry Vilboux, Luis M Gomez, Kathi Huddleston, Wendy S W Wong, John E Niederhuber, Thomas P Conrads and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Prachi KothiyalInova Health System, Falls Church, VA, USA. pkothiyal@symbioseq.com.
Keriann SchulkersInova Children's Hospital, Falls Church, VA, USA.
Xinyue LiuInova Health System, Falls Church, VA, USA.
Sahel HazratiInova Health System, Falls Church, VA, USA.
Thierry VilbouxPersona Biomed, Inc., Alexandria, VA, USA.
Luis M GomezWomen's Service Line and the Women's Health Integrated Research Center, Inova Health System, Falls Church, VA, USA.
Kathi HuddlestonInova Health System, Falls Church, VA, USA.
Wendy S W WongInova Health System, Falls Church, VA, USA.
John E NiederhuberDepartments of Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thomas P ConradsWomen's Service Line and the Women's Health Integrated Research Center, Inova Health System, Falls Church, VA, USA.
G Larry MaxwellWomen's Service Line and the Women's Health Integrated Research Center, Inova Health System, Falls Church, VA, USA.
Suchitra K HouriganInova Children's Hospital, Falls Church, VA, USA.
Inova Health System · USInova Children's Hospital · USGeorge Mason University · USJohns Hopkins Medicine · US

Funding

The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.K23HD099240 · NICHD · INOVA HEALTH CARE SERVICES · PI HOURIGAN, SUCHITRA · 2019 to 2021
$476k
NICHD NIH HHS K23 HD099240NICHD NIH HHS K23HD099240
6 · The paper itself

Abstract

Cesarean section (CS) is recognized as being a shared environmental risk factor associated with chronic immune disease. A study of maternal gene expression changes between different delivery modes can add to our understanding of how CS contributes to disease patterns later in life. We evaluated the association of delivery mode with postpartum gene expression using a cross-sectional study of 324 mothers who delivered full-term (≥ 37 weeks) singletons. Of these, 181 mothers had a vaginal delivery and 143 had a CS delivery (60 with and 83 without labor). Antimicrobial peptides (AMP) were upregulated in vaginal delivery compared to CS with or without labor. Peptidase inhibitor 3 (PI3), a gene in the antimicrobial peptide pathway and known to be involved in antimicrobial and anti-inflammatory activities, showed a twofold increase in vaginal delivery compared to CS with or without labor (adjusted p-value 1.57 × 10

Indexed as

AdultCesarean SectionCross-Sectional StudiesDelivery, ObstetricElafinFemaleGene Expression RegulationHumansLabor, ObstetricPore Forming Cytotoxic ProteinsPostpartum PeriodPregnancyTranscriptomeUp-RegulationElafinPore Forming Cytotoxic Proteins

Identifiers

PMID33082495
PMCPMC7576122
OpenAlexW3093497772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.