Evidence map›Paper›PMID 33082370›Full record

ArticleScientific reports2020

Deletion of CD38 and supplementation of NAD

Yuji Takaso, Masao Noda, Tsuyoshi Hattori, Jureepon Roboon, Miyako Hatano, Hisashi Sugimoto, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. The role of NADnpj metabolic health and disease · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Nicotinamide Adenine Dinucleotide (NADAntioxidants & redox signaling · 2023
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yuji TakasoDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Masao NodaDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Tsuyoshi HattoriDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.
Jureepon RoboonDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.
Miyako HatanoDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hisashi SugimotoDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Charles BrennerDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, USA.
Yasuhiko YamamotoDepartment of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hiroshi OkamotoDepartment of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Haruhiro HigashidaResearch Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.
Makoto ItoDepartment of Pediatric Otolaryngology, Jichi Children's Medical Center Tochigi, Jichi Medical University, Tochigi, Japan.
Tomokazu YoshizakiDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Osamu HoriDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan. osamuh3@staff.kanazawa-u.ac.jp.
Kanazawa University · JPJichi Medical University · JPTohoku University · JPUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following facial nerve axotomy, nerve function is not fully restored even after reconstruction. This may be attributed to axon degeneration/neuronal death and sustained neuroinflammation. CD38 is an enzyme that catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD

Indexed as

ADP-ribosyl Cyclase 1AnimalsAxonsAxotomyCell CountCells, CulturedDietary SupplementsDisease Models, AnimalFacial NerveFacial Nerve DiseasesHumansMiceMice, Inbred ICRMice, KnockoutNADNerve DegenerationADP-ribosyl Cyclase 1NAD

Identifiers

PMID33082370
PMCPMC7576594
OpenAlexW3094620497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.