Evidence map›Paper›PMID 33082340›Full record

ArticleScientific data2020

A three-dimensional thalamocortical dataset for characterizing brain heterogeneity.

Judy A Prasad, Aishwarya H Balwani, Erik C Johnson, Joseph D Miano, Vandana Sampathkumar, Vincent De Andrade, Kamel Fezzaa, Ming Du, Rafael Vescovi, Chris Jacobsen and 5 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Judy A PrasadDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6990-9333
Aishwarya H BalwaniSchool of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-9234-1632
Erik C JohnsonApplied Physics Laboratory, Johns Hopkins University, Laurel, MD, USA.
Joseph D MianoCollege of Computing, Georgia Institute of Technology, Atlanta, GA, USA.
Vandana SampathkumarDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.
Vincent De AndradeAdvanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.
Kamel FezzaaAdvanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.ORCID 0000-0001-6135-8450
Ming DuAdvanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.
Rafael VescoviAdvanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.ORCID 0000-0002-0652-1128
Chris JacobsenAdvanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.ORCID 0000-0001-8562-0353
Konrad P KordingDepartment of Biomedical Engineering, University of Pennsylvania, Philadelpha, PA, USA.ORCID 0000-0001-8408-4499
Doga GürsoyAdvanced Photon Source, Argonne National Laboratory, Argonne, IL, USA.
William Gray RoncalApplied Physics Laboratory, Johns Hopkins University, Laurel, MD, USA.
Narayanan KasthuriDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.
Eva L DyerSchool of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA. evadyer@gatech.edu.

Funding

Boss: A cloud-based data archive for electron microscopy and x-ray microtomographyR24MH114785 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BROCK A. WESTER · 2018 to 2026
$6.9M
Thalamocortical interactionsR01NS094184 · NINDS · UNIVERSITY OF CHICAGO · PI Jason Neil MacLean, S. Murray SHERMAN · 2016 to 2026
$4.6M
Connectome of circuits within and between thalamus and cortexR01NS113922 · NINDS · UNIVERSITY OF CHICAGO · PI KASTHURI, NARAYANAN, SHERMAN, S. MURRAY · 2020 to 2024
$2.8M
Sub-micrometer x-ray tomography for neuroanatomyU01MH109100 · NIMH · NORTHWESTERN UNIVERSITY · PI JACOBSEN, CHRIS JOHNSON, KASTHURI, NARAYANAN · 2015 to 2017
$2.0M
Development of Sub 100 nm Resolution X-ray Nanotomography of Centimeter-Sized TissuesR01MH115265 · NIMH · NORTHWESTERN UNIVERSITY · PI JACOBSEN, CHRIS JOHNSON · 2018 to 2021
$1.5M
SABER: Scalable Analytics for Brain Exploration Research using X-Ray Microtomography and Electron MicroscopyR24MH114799 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRAY RONCAL, WILLIAM R · 2017 to 2019
$1.2M
NIMH NIH HHS R01 MH115265NIMH NIH HHS R24 MH114785NIMH NIH HHS R24 MH114799NIMH NIH HHS U01 MH109100NINDS NIH HHS R01 NS094184NINDS NIH HHS R01 NS113922
6 · The paper itself

Abstract

Neural microarchitecture is heterogeneous, varying both across and within brain regions. The consistent identification of regions of interest is one of the most critical aspects in examining neurocircuitry, as these structures serve as the vital landmarks with which to map brain pathways. Access to continuous, three-dimensional volumes that span multiple brain areas not only provides richer context for identifying such landmarks, but also enables a deeper probing of the microstructures within. Here, we describe a three-dimensional X-ray microtomography imaging dataset of a well-known and validated thalamocortical sample, encompassing a range of cortical and subcortical structures from the mouse brain . In doing so, we provide the field with access to a micron-scale anatomical imaging dataset ideal for studying heterogeneity of neural structure.

Indexed as

Brain MappingImaging, Three-DimensionalX-Ray MicrotomographyAnimalsBrainMice

Identifiers

PMID33082340
PMCPMC7576781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.