Evidence map›Paper›PMID 33082339›Full record

ArticleNature communications2020

AKAP5 complex facilitates purinergic modulation of vascular L-type Ca

Maria Paz Prada, Arsalan U Syed, Gopireddy R Reddy, Miguel Martín-Aragón Baudel, Víctor A Flores-Tamez, Kent C Sasse, Sean M Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 45 citations in OpenAlex.

  1. Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.bioRxiv : the preprint server for biology · 2026
    Article
  2. CaThe Journal of physiology · 2026
    Article
  3. Review
  4. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  5. Stimulation of CaScience signaling · 2025
    Article
  6. Article
  7. CaInflammation and regeneration · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. α1Journal of the American Heart Association · 2024
    Article
  13. Aberrant splicing of CaCellular and molecular life sciences : CMLS · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. NPC1-dependent alterations in KNature communications · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Maria Paz PradaDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.
Arsalan U SyedDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.
Gopireddy R ReddyDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.
Miguel Martín-Aragón BaudelDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0001-9399-4013
Víctor A Flores-TamezDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0001-8369-9192
Kent C SasseSasse Surgical Associates, Reno, NV, 89502, USA.
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada Reno, Reno, NV, 89557, USA.
Padmini SirishDepartment of Internal Medicine, University of California Davis, Davis, CA, 95616, USA.
Nipavan ChiamvimonvatDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.
Peter BartelsDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0001-5852-1835
Eamonn J DicksonDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, 95616, USA.
Johannes W HellDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0001-7960-7531
John D ScottDepartment of Pharmacology, University of Washington Seattle, Seattle, WA, 98195, USA.
Luis F SantanaDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, 95616, USA.
Yang K XiangDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0003-1786-9143
Manuel F NavedoDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA. mfnavedo@ucdavis.edu.ORCID 0000-0001-6864-6594
Madeline Nieves-CintrónDepartment of Pharmacology, University of California Davis, Davis, CA, 95616, USA. mcnieves@ucdavis.edu.ORCID 0000-0003-1935-8400
University of California, Davis · USVA Northern California Health Care System · USUniversity of Nevada, Reno · USUniversity of Washington · US

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Defective PKA Signaling in Cushing's SyndromeR01DK119192 · NIDDK · UNIVERSITY OF WASHINGTON · PI John D Scott · 2018 to 2026
$4.4M
Role of a-actinin in Cav1.2 FunctionR01AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2016 to 2026
$4.0M
Calcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5M
Cerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7M
Insulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Tuning L-Type Ca Channel Activity in Arterial Smooth Muscle by Kv Channel-Mediated ClusteringR01HL144071 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANTANA, LUIS F, TRIMMER, JAMES S · 2018 to 2021
$2.0M
Membrane contact sites regulate cellular excitabilityR01GM127513 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES · 2019 to 2023
$1.6M
Cardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR SignalingR01HL112413 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$1.6M
AKAP Modulation of Renal SignalingR01DK119186 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL112413NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL127764NHLBI NIH HHS R01 HL144071NHLBI NIH HHS R01 HL149127NHLBI NIH HHS T32 HL086350NIA NIH HHS R01 AG055357NIDDK NIH HHS R01 DK105542NIDDK NIH HHS R01 DK119186NIDDK NIH HHS R01 DK119192NIGMS NIH HHS R01 GM127513NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

The L-type Ca

Indexed as

A Kinase Anchor ProteinsAnimalsArteriesCalcium Channels, L-TypeCyclic AMPGlucoseHyperglycemiaMice, KnockoutMuscle CellsProtein BindingAKAP5 protein, humanAkap5 protein, mouseA Kinase Anchor ProteinsCACNA1C protein, humanCACNA1C protein, mouseCalcium Channels, L-TypeCyclic AMPGlucose

Identifiers

PMID33082339
PMCPMC7575592
OpenAlexW3093608721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.