ArticleNature communications2020
Prevalent and sex-biased breathing patterns modify functional connectivity MRI in young adults.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results.Neuroscience and biobehavioral reviews · 2023Pooled it
- From Lung to Brain: Respiration Modulates Neural and Mental Activity.Neuroscience bulletin · 2023Pooled it
- Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed Respiratory Fluctuations.Magnetic resonance in medicine · 2026Article
- Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI.Brain and behavior · 2025Article
- Sleep state-dependent development of resting-state functional connectivity during the preterm period.Sleep · 2024Article
- Brain-wide functional connectivity artifactually inflates throughout functional magnetic resonance imaging scans.Nature human behaviour · 2024Article
- Widespread Autonomic Physiological Coupling Across the Brain-Body Axis.bioRxiv : the preprint server for biology · 2024Article
- Managing Cancer and Living Meaningfully (CALM) alleviates chemotherapy related cognitive impairment (CRCI) in breast cancer survivors: A pilot study based on resting-state fMRI.Cancer medicine · 2023Article
- Article
- Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI.NPJ digital medicine · 2023Article
- Graph-matching distance between individuals' functional connectomes varies with relatedness, age, and cognitive score.Human brain mapping · 2023Article
- Article
- Functional Connectivity Mapping for rTMS Target Selection in Depression.The American journal of psychiatry · 2023Article
- Uncovering individual differences in fine-scale dynamics of functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Controversies and progress on standardization of large-scale brain network nomenclature.Network neuroscience (Cambridge, Mass.) · 2023Article
- Cerebrovascular activity is a major factor in the cerebrospinal fluid flow dynamics.NeuroImage · 2022Article
- A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function.NeuroImage · 2021Article
- Revisiting the neurovascular unit.Nature neuroscience · 2021Review
- Rapid Precision Functional Mapping of Individuals Using Multi-Echo fMRI.Cell reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Resting state functional connectivity magnetic resonance imaging (fMRI) is a tool for investigating human brain organization. Here we identify, visually and algorithmically, two prevalent influences on fMRI signals during 440 h of resting state scans in 440 healthy young adults, both caused by deviations from normal breathing which we term deep breaths and bursts. The two respiratory patterns have distinct influences on fMRI signals and signal covariance, distinct timescales, distinct cardiovascular correlates, and distinct tendencies to manifest by sex. Deep breaths are not sex-biased. Bursts, which are serial taperings of respiratory depth typically spanning minutes at a time, are more common in males. Bursts share features of chemoreflex-driven clinical breathing patterns that also occur primarily in males, with notable neurological, psychiatric, medical, and lifespan associations. These results identify common breathing patterns in healthy young adults with distinct influences on functional connectivity and an ability to differentially influence resting state fMRI studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.