ArticleScience signaling2020
Interclass GPCR heteromerization affects localization and trafficking.
Open access · greenAbstract read
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Article in Science signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
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- Principles and Design of Molecular Tools for Sensing and Perturbing Cell Surface Receptor Activity.Chemical reviews · 2025Review
- Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon.Developmental cell · 2024Article
- Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HTNeurochemical research · 2024Article
- Membrane Permeation of Psychedelic Tryptamines by Dynamic Simulations.Biochemistry · 2024Article
- Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics.Molecular psychiatry · 2023Review
- Ligand-Free Signaling of G-Protein-Coupled Receptors: Physiology, Pharmacology, and Genetics.Molecules (Basel, Switzerland) · 2023Review
- The crosstalk between 5-HTNeuropharmacology · 2023Review
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- Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.Journal of virology · 2023Article
- Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors.Science (New York, N.Y.) · 2023Article
- The role of thalamic group II mGlu receptors in health and disease.Neuronal signaling · 2022Review
- Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HTACS chemical neuroscience · 2022Article
- Effects of acute lysergic acid diethylamide on intermittent ethanol and sucrose drinking and intracranial self-stimulation in C57BL/6 mice.Journal of psychopharmacology (Oxford, England) · 2022Article
- Sex-specific role for serotonin 5-HTNeuropharmacology · 2022Article
- Orthogonal Peptide-Templated Labeling Elucidates Lateral ETChembiochem : a European journal of chemical biology · 2022Article
- Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity.Biochemistry · 2022Review
- Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism.Science advances · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Rudy ToneattiDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0002-0648-1824
Jong M ShinDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0003-1957-7419
Urjita H ShahDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Carl R MayerDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23220, USA.
Justin M SaundersDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0003-4131-9205
Miguel FribourgDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-1804-8136
Paul T ArsenovicDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23220, USA.
William G JanssenDepartment Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-3954-7866
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Juan F López-GiménezDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0003-3021-6200
Deanna L BensonDepartment Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-7037-1147
Daniel E ConwayDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23220, USA.ORCID 0000-0001-6624-177X
Javier González-MaesoDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA. javier.maeso@vcuhealth.org.ORCID 0000-0003-3105-3204
Virginia Commonwealth University · USIcahn School of Medicine at Mount Sinai · US
Funding
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0MMOLECULAR MECHANISM OF AGONISM AT THE GNRH RECEPTORR01DK046943 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI STUART C. SEALFON · 1993 to 2026
$11.0MStructure and function of the 5HT2A/mGluR2 complex in schizophreniaR01MH084894 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Javier Gonzalez-Maeso · 2009 to 2026
$6.8MCell junction and nuclear forces as mediators of epithelial cell homeostasisR35GM119617 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Daniel E Conway · 2016 to 2026
$4.5MDevelopmentally sensitive regulatory mechanisms of synapse assembly and functionR01MH103455 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, GUNAL, OZLEM · 2014 to 2018
$2.1MPreclinical role of HDAC2 in mGlu2-dependent schizophrenia treatmentR01MH111940 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI GONZÁLEZ-MAESO, JAVIER · 2017 to 2021
$1.5MGut dysbiosis and 5-HT2A dysregulation in a preclinical schizophrenia modelF30MH116550 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAUNDERS, JUSTIN M · 2018 to 2021
$151kNCI NIH HHS P30 CA016059NIDDK NIH HHS R01 DK046943NIGMS NIH HHS R35 GM119617NIMH NIH HHS F30 MH116550NIMH NIH HHS R01 MH084894NIMH NIH HHS R01 MH103455NIMH NIH HHS R01 MH111940
Abstract
Membrane trafficking processes regulate G protein-coupled receptor (GPCR) activity. Although class A GPCRs are capable of activating G proteins in a monomeric form, they can also potentially assemble into functional GPCR heteromers. Here, we showed that the class A serotonin 5-HT
Indexed as
Signal TransductionAmino AcidsAnimalsBridged Bicyclo Compounds, HeterocyclicCell MembraneClozapineEndosomesHEK293 CellsHumansMice, 129 StrainMice, KnockoutMicroscopy, ConfocalMultiprotein ComplexesProtein MultimerizationProtein TransportReceptor, Serotonin, 5-HT2AAmino AcidsBridged Bicyclo Compounds, HeterocyclicClozapineLY 379268metabotropic glutamate receptor 2Multiprotein ComplexesReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSerotonin Antagonists
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.