ArticlemSystems2020
Long-Term Temporal Stability of the Resistome in Sewage from Copenhagen.
Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A comprehensive database for biological data derived from sewage in five European cities.Database : the journal of biological databases and curation · 2026Article
- Urban wastewater and sewage sludge as environmental sources of antimicrobial resistance, potential pathogens, and selective agents: insights from three European wastewater treatment plants.Frontiers in cellular and infection microbiology · 2026Article
- Deep metatranscriptomic sequencing data of wastewater from Los Angeles, USA, 2023-2024.Scientific data · 2025Article
- The surveillance of antimicrobial resistance in wastewater from a one health perspective: A global scoping and temporal review (2014-2024).One health (Amsterdam, Netherlands) · 2025Article
- Using wastewater surveillance to investigate community-level differences in antibacterial resistance in a major urban center, USA.Applied and environmental microbiology · 2025Article
- A Practical Framework for Environmental Antibiotic Resistance Monitoring in Freshwater Ecosystems.Antibiotics (Basel, Switzerland) · 2025Review
- Characterization of antibiotic resistance development ofbioRxiv : the preprint server for biology · 2024Article
- Metagenomic Profiling of Internationally Sourced Sewage Influents and Effluents Yields Insight into Selecting Targets for Antibiotic Resistance Monitoring.Environmental science & technology · 2024Article
- Time-series sewage metagenomics distinguishes seasonal, human-derived and environmental microbial communities potentially allowing source-attributed surveillance.Nature communications · 2024Article
- Discovery of Vibrio cholerae in Urban Sewage in Copenhagen, Denmark.Microbial ecology · 2024Article
- ARGprofiler-a pipeline for large-scale analysis of antimicrobial resistance genes and their flanking regions in metagenomic datasets.Bioinformatics (Oxford, England) · 2024Article
- Towards facilitated interpretation of shotgun metagenomics long-read sequencing data analyzed with KMA for the detection of bacterial pathogens and their antimicrobial resistance genes.Frontiers in microbiology · 2024Article
- Long-term antibiotic exposure landscapes and resistant Escherichia coli colonization in a densely populated setting.PloS one · 2024Article
- Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance.Nature communications · 2022Article
- Global Distribution ofmSystems · 2022Article
- Computational Model To Quantify the Growth of Antibiotic-Resistant Bacteria in Wastewater.mSystems · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance (AMR) is a major threat to global health, and it is crucial to understand the epidemiological aspects in order to predict the emergence and propagation of AMR genes. The aim of this study was to assess the variability and medium-term AMR trends within the mostly healthy human population of a single city. We monitored over 36 months (November 2015 to November 2018) the AMR level in the city of Copenhagen, Denmark, by taking bi-weekly sewage samples from the inlets of the three main water treatment plants, extracting the DNA, performing metagenomic sequencing, and read-mapping against a database of known AMR genes. We found that the AMR level was surprisingly stable with no periodic variability and no signs of drift over the measured period. We found, however, that the seemingly random variations at each site correlate in time with each other, suggesting that the variations we see are due to real environmental changes in the occurrence of AMR.
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Registered trials
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