Evidence map›Paper›PMID 33082270›Full record

ArticleG3 (Bethesda, Md.)2020

Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in

Matthew D Berg, Yanrui Zhu, Joshua Isaacson, Julie Genereaux, Raphaël Loll-Krippleber, Grant W Brown, Christopher J Brandl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Mistranslating tRNA variants impact the proteome and phosphoproteome ofbioRxiv : the preprint server for biology · 2025
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  4. bioRxiv : the preprint server for biology · 2024
    Article
  5. Genetic inactivation of essentialMolecular biology of the cell · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew D BergDepartment of Biochemistry, The University of Western Ontario, London, Canada mberg2@uwo.ca cbrandl@uwo.ca.ORCID 0000-0002-7924-9241
Yanrui ZhuDepartment of Biochemistry, The University of Western Ontario, London, Canada.
Joshua IsaacsonDepartment of Biology, The University of Western Ontario, London, Canada.
Julie GenereauxDepartment of Biochemistry, The University of Western Ontario, London, Canada.
Raphaël Loll-KrippleberDonnelly Centre for Cellular and Biomolecular Research and Department of Biochemistry, University of Toronto, Toronto, Canada.
Grant W BrownDonnelly Centre for Cellular and Biomolecular Research and Department of Biochemistry, University of Toronto, Toronto, Canada.ORCID 0000-0002-9002-5003
Christopher J BrandlDepartment of Biochemistry, The University of Western Ontario, London, Canada mberg2@uwo.ca cbrandl@uwo.ca.ORCID 0000-0001-8015-9668
Western University · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-proteinogenic amino acids, such as the proline analog L-azetidine-2-carboxylic acid (AZC), are detrimental to cells because they are mis-incorporated into proteins and lead to proteotoxic stress. Our goal was to identify genes that show chemical-genetic interactions with AZC in

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAzetidinecarboxylic AcidGonadotropin-Releasing HormoneProlineAzetidinecarboxylic AcidGonadotropin-Releasing HormoneLHRH, Ac-Nal(1)-Cpa(2)-Pal(3,6)-Arg(5)-Ala(10)-ProlineSaccharomyces cerevisiae Proteinsactin cytoskeletonL-azetidine-2-carboxylic acidmistranslationprotein quality controlproteotoxic stressSaccharomyces cerevisiae

Identifiers

PMID33082270
PMCPMC7718759
OpenAlexW3094163937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.