Evidence map›Paper›PMID 33081983›Full record

Trial reportClinical nutrition (Edinburgh, Scotland)2021

Effect of nutritional support in patients with lower respiratory tract infection: Secondary analysis of a randomized clinical trial.

Annic Baumgartner, Flavia Hasenboehler, Jennifer Cantone, Lara Hersberger, Annika Bargetzi, Laura Bargetzi, Nina Kaegi-Braun, Pascal Tribolet, Filomena Gomes, Claus Hoess and 13 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02517476 (Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02517476 phase4completednot on this map

Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial: The EFFORT Trial

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2014 to 2018Enrolled2,088ConditionsMalnutritionArmsNutritional therapy
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Guideline
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  13. Subclinical Kwashiorkor in Adults: A New Age Paradigm.Indian journal of endocrinology and metabolism
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 2 countries.

Annic BaumgartnerMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Flavia HasenboehlerMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Jennifer CantoneMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Lara HersbergerMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Annika BargetziMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Laura BargetziMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Nina Kaegi-BraunMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland.
Pascal TriboletInternal Medicine, Spital Lachen, Switzerland; Department of Health Professions, Bern University of Applied Sciences, Bern, Switzerland.
Filomena GomesMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; The New York Academy of Sciences, New York City, NY, USA.
Claus HoessInternal Medicine, Kantonsspital Muensterlingen, Switzerland.
Vojtech PavlicekInternal Medicine, Kantonsspital Muensterlingen, Switzerland.
Stefan BilzInternal Medicine & Endocrinology/Diabetes, Kantonsspital St.Gallen, Switzerland.
Sarah SigristInternal Medicine & Endocrinology/Diabetes, Kantonsspital St.Gallen, Switzerland.
Michael BrändleInternal Medicine & Endocrinology/Diabetes, Kantonsspital St.Gallen, Switzerland.
Christoph HenzenInternal Medicine, Kantonsspital Luzern, Switzerland.
Robert ThomannDepartment of Internal Medicine, Buergerspital Solothurn, Switzerland.
Jonas RutishauserInternal Medicine, Kantonsspital Baselland, Switzerland.
Drahomir AujeskyDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Nicolas RodondiDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Institute of Primary Health Care (BIHAM), University of Bern, Switzerland.
Jacques DonzéDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Neuchâtel Hospital Network, Neuchâtel, Switzerland.
Zeno StangaDivision of Diabetology, Endocrinology, Nutritional Medicine & Metabolism, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Beat MuellerMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
Philipp SchuetzMedical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland. Electronic address: schuetzph@gmail.com.
University of Basel · CHUniversity of Bern · CHKantonsspital St. Gallen · CHKantonsspital Münsterlingen · CHBern University of Applied Sciences · CHKantonsspital Aarau · CHKantonsspital Baselland · CHLuzerner Kantonsspital · CHNew York Academy of Sciences · USSolothurner Spitäler · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn polymorbid patients with bronchopulmonary infection, malnutrition is an independent risk factor for mortality. There is a lack of interventional data investigating whether providing nutritional support during the hospital stay in patients at risk for malnutrition presenting with lower respiratory tract infection lowers mortality.

methodsFor this secondary analysis of a randomized clinical trial (EFFORT), we analyzed data of a subgroup of patients with confirmed lower respiratory tract infection from an initial cohort of 2028 patients. Patients at nutritional risk (Nutritional Risk Screening [NRS] score ≥3 points) were randomized to receive protocol-guided individualized nutritional support to reach protein and energy goals (intervention group) or standard hospital food (control group). The primary endpoint of this analysis was all-cause 30-day mortality.

resultsWe included 378 of 2028 EFFORT patients (mean age 74.4 years, 24% with COPD) into this analysis. Compared to usual care hospital nutrition, individualized nutritional support to reach caloric and protein goals showed a similar beneficial effect of on the risk of mortality in the subgroup of respiratory tract infection patients as compared to the main EFFORT trial (odds ratio 0.47 [95%CI 0.17 to 1.27, p = 0.136] vs 0.65 [95%CI 0.47 to 0.91, p = 0.011]) with no evidence of a subgroup effect (p for interaction 0.859). Effects were also similar among different subgroups based on etiology and type of respiratory tract infection and for other secondary endpoints.

conclusionThis subgroup analysis from a large nutrition support trial suggests that patients at nutritional risk as assessed by NRS 2002 presenting with bronchopulmonary infection to the hospital likely have a mortality benefit from individualized inhospital nutritional support. The small sample size and limited statistical power calls for larger nutritional studies focusing on this highly vulnerable patient population. CLINICAL

trial registrationRegistered under ClinicalTrials.gov Identifier no. NCT02517476.

Indexed as

AgedCohort StudiesComorbidityFemaleHospitalizationHumansMaleMalnutritionMiddle AgedNutritional SupportRespiratory Tract InfectionsSwitzerlandCOVID19MalnutritionNutritional supportOutcomeRandomized trialRespiratory infection

Identifiers

PMID33081983
PMCPMC7547398
OpenAlexW3092586142

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.