ArticleBMC infectious diseases2020
Clinical features of gingivostomatitis due to primary infection of herpes simplex virus in children.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of Systemic Pathologies on Dental, Periodontal and Orthodontic Status in Children.Biomedicines · 2025Article
- Article
- Striking Oral Manifestation of Primary Herpetic Gingivostomatitis: A Case Report and Review of Human Herpesvirus Infections.International medical case reports journal · 2025Article
- Antiviral activity ofIranian journal of microbiology · 2024Article
- Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus.Journal of personalized medicine · 2024Review
- Viral Infections of the Oral Cavity in Children.Children (Basel, Switzerland) · 2023Article
- The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?Infection and drug resistance · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPrimary herpetic gingivostomatitis (PHGS) in children, though usually self-limited, might mimic bacterial and enteroviral pharyngitis clinically. We conducted a study to define the clinical features of PHGS in children.
methodsBetween January 2012 and December 2016, 282 inpatients aged less than 19 years with cell culture-confirmed herpes simplex virus (HSV) infection in a medical center were identified from the virologic laboratory logbook. Clinical data were retrospectively collected.
resultsAmong the 282 inpatients, 185 cases were considered as PHGS and were included for analysis. Fever was present in 99.5%. The mean duration of fever was 5.11 days (±2.24) with the longest being 17 days. Common oral manifestations included oral ulcers (84.3%), which equally resided in the anterior and posterior part of the oral cavity (65.4% vs. 63.2%), gum swelling and/or bleeding (67.6%), and exudate coated tonsils (16.8%). Leukocytosis (WBC count > 15,000/uL
conclusionsMeticulously identifying specific oral manifestations of gum swelling/bleeding and ulcers over the anterior oral cavity in children can help making the diagnosis of PHGS earlier and subsequently reduce unnecessary prescription of antibiotics.
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