Evidence map›Paper›PMID 33081641›Full record

ArticleProceedings. Biological sciences2020

Krüppel-like factor/specificity protein evolution in the Spiralia and the implications for cephalopod visual system novelties.

Kyle J McCulloch, Kristen M Koenig

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings. Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kyle J McCullochDepartment of Organismic and Evolutionary Biology, Harvard University Cambridge, MA 02138, USA.
Kristen M KoenigDepartment of Organismic and Evolutionary Biology, Harvard University Cambridge, MA 02138, USA.
Harvard University · US

Funding

Investigating Organ Formation and the Emergence of Complexity in the Visual System Using Comparative Developmental ApproachesDP5OD023111 · OD · HARVARD UNIVERSITY · PI KOENIG, KRISTEN MARIE · 2016 to 2020
$2.1M
NIH HHS DP5 OD023111
6 · The paper itself

Abstract

The cephalopod visual system is an exquisite example of convergence in biological complexity. However, we have little understanding of the genetic and molecular mechanisms underpinning its elaboration. The generation of new genetic material is considered a significant contributor to the evolution of biological novelty. We sought to understand if this mechanism may be contributing to cephalopod-specific visual system novelties. Specifically, we identified duplications in the Krüppel-like factor/specificity protein (KLF/SP) sub-family of C2H2 zinc-finger transcription factors in the squid

Indexed as

AnimalsCephalopodaDecapodiformesEvolution, MolecularGene DuplicationGene Expression Regulation, DevelopmentalKruppel-Like Transcription FactorsPhylogenySensitivity and SpecificityTranscription FactorsVision, OcularKruppel-Like Transcription FactorsTranscription Factorscephalopodeye evolutionlensneofunctionalizationSpiraliatranscription factor

Identifiers

PMID33081641
PMCPMC7661307
OpenAlexW3094243983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.