Evidence map›Paper›PMID 33081638›Full record

ReviewOpen biology2020

The structure and function of deubiquitinases: lessons from budding yeast.

Harsha Garadi Suresh, Natasha Pascoe, Brenda Andrews

Open access · goldAbstract readReview
In one paragraph

Review in Open biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  15. Article
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  17. Article
  18. The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review.Frontiers in cellular and infection microbiology · 2022
    Review
  19. Role of USP13 in physiology and diseases.Frontiers in molecular biosciences · 2022
    Review
  20. The Deubiquitinating EnzymeFrontiers in fungal biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Harsha Garadi SureshDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada M5S 3E1.
Natasha PascoeDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada M5S 3E1.
Brenda AndrewsDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada M5S 3E1.
University of Toronto · CA

Funding

CIHR FDN-143265
6 · The paper itself

Abstract

Protein ubiquitination is a key post-translational modification that regulates diverse cellular processes in eukaryotic cells. The specificity of ubiquitin (Ub) signalling for different bioprocesses and pathways is dictated by the large variety of mono-ubiquitination and polyubiquitination events, including many possible chain architectures. Deubiquitinases (DUBs) reverse or edit Ub signals with high sophistication and specificity, forming an integral arm of the Ub signalling machinery, thus impinging on fundamental cellular processes including DNA damage repair, gene expression, protein quality control and organellar integrity. In this review, we discuss the many layers of DUB function and regulation, with a focus on insights gained from budding yeast. Our review provides a framework to understand key aspects of DUB biology.

Indexed as

Cell CycleChromosome SegregationDeubiquitinating EnzymesExophthalmosGene Expression RegulationMultigene FamilyProtein ConformationProtein Interaction Domains and MotifsProtein Processing, Post-TranslationalProteolysisProteostasisSaccharomycetalesSignal TransductionStructure-Activity RelationshipSubstrate SpecificityUbiquitinDeubiquitinating EnzymesUbiquitindeubiquitinasesprotein degradationubiquitin signalling

Identifiers

PMID33081638
PMCPMC7653365
OpenAlexW3094384537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.