Evidence map›Paper›PMID 33081637›Full record

ArticleOpen biology2020

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn

Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P Turkenburg and 3 more

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Therapeutic potential of zincFrontiers in pharmacology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Experimental Approaches to Diabetes Mellitus.The Eurasian journal of medicine · 2022
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Petra DzianováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Seiya AsaiInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Martina ChrudinováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Lucie KosinováLaboratory of Pancreatic Islets, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.
Pavlo PotalitsynInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Pavel ŠáchaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Romana HadravováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Irena SelicharováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Jan KřížLaboratory of Pancreatic Islets, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.
Johan P TurkenburgYork Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, United Kingdom.
Andrzej Marek BrzozowskiYork Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, United Kingdom.
Jiří JiráčekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Lenka ŽákováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10 Prague 6, Czech Republic.
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZCharles University · CZInstitute of Microbiology · BYScience City York (United Kingdom) · GB

Funding

Medical Research Council MR/K000179/1Medical Research Council MR/R009066/1
6 · The paper itself

Abstract

Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn

Indexed as

Gene ExpressionAnimalsChemical FractionationCytoplasmic GranulesFlow CytometryGlucoseInsulinInsulin-Secreting CellsIslets of LangerhansMaleRatsRNA, MessengerZincZinc Transporter 8GlucoseInsulinRNA, MessengerSlc30a8 protein, ratZincZinc Transporter 8insulinpancreatic isletsproinsulinzinc ionsznt8β-cells

Identifiers

PMID33081637
PMCPMC7653362
OpenAlexW3094428757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.