Evidence map›Paper›PMID 33081612›Full record

ArticleProceedings. Biological sciences2020

Mutation bias can shape adaptation in large asexual populations experiencing clonal interference.

Kevin Gomez, Jason Bertram, Joanna Masel

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Module-Selection Balance in the Evolution of Modular Organisms.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Shifts in mutation spectra enhance access to beneficial mutations.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Mutation bias and the predictability of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  10. Article
  11. Exploring the expanse between theoretical questions and experimental approaches in the modern study of evolvability.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023
    Article
  12. Article
  13. Mutation bias shapes the spectrum of adaptive substitutions.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Evolutionary stalling and a limit on the power of natural selection to improve a cellular module.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin GomezGraduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, AZ, USA.
Jason BertramEnvironmental Resilience Institute, Indiana University, Bloomington, IN, USA.
Joanna MaselDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.

Funding

Computational and Mathematical Modeling of Biomedical SystemsT32GM084905 · NIGMS · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2009 to 2018
$2.2M
NIGMS NIH HHS T32 GM084905
6 · The paper itself

Abstract

The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which in population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes mutation-biased adaptation rare. We consider the behaviour of two simultaneously adapting traits, one with larger mutation rate

Indexed as

Genetics, PopulationMutation RateAdaptation, PhysiologicalMutationReproduction, Asexualdevelopmental biaselasticitymodern synthesismutation-driven adaptationparallel adaptationstandard evolutionary theory

Identifiers

PMID33081612
PMCPMC7661309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.