Evidence map›Paper›PMID 33081571›Full record

ReviewExpert review of medical devices2020

Deep brain stimulation and other surgical modalities for the management of essential tremor.

Kai-Liang Wang, Qianwei Ren, Shannon Chiu, Bhavana Patel, Fan-Gang Meng, Wei Hu, Aparna Wagle Shukla

Abstract readReview
In one paragraph

Review in Expert review of medical devices, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Gamma knife thalamotomy provides durable long-term relief from essential tremor: a 30-year single institution experience.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  4. Article
  5. Diagnosis and Treatment of Essential Tremor.Continuum (Minneapolis, Minn.) · 2022
    Review
  6. Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kai-Liang WangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University , Beijing, China.
Qianwei RenDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University , Beijing, China.
Shannon ChiuDepartment of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.
Bhavana PatelDepartment of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.
Fan-Gang MengDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University , Beijing, China.
Wei HuDepartment of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.
Aparna Wagle ShuklaDepartment of Neurology, University of Florida College of Medicine , Gainesville, FL, USA.

Funding

Functional Brain Networks in Essential Tremor and Dystonic TremorK23NS092957 · NINDS · UNIVERSITY OF FLORIDA · PI WAGLE SHUKLA, APARNA · 2016 to 2019
$703k
NINDS NIH HHS K23 NS092957
6 · The paper itself

Abstract

introductionSurgical treatments are considered for essential tremor (ET) when patients do not respond to oral pharmacological therapies. These treatments mainly comprise radiofrequency (RF) thalamotomy, gamma knife radiosurgery (GKRS), deep brain stimulation (DBS), and focused ultrasound (FUS) procedures. AREAS COVERED: We reviewed the strengths and weaknesses of each procedure and clinical outcomes for 7 RF studies (n = 85), 11 GKRS (n = 477), 33 DBS (n = 1061), and 13 FUS studies (n = 368). A formal comparison was not possible given the heterogeneity in studies. Improvements were about 42%-90% RF, 10%-79% GKRS, 45%-83% DBS, 42%-83% FUS at short-term follow-up (<12 months) and were about 54%-82% RF, 11%-84% GKRS, 18%-92% DBS, and 42%-80% FUS at long-term follow-up (>12 months). EXPERT OPINION: We found DBS with inherent advantages of being an adjustable and reversible procedure as the most frequently employed surgical procedure for control of ET symptoms. FUS is a promising procedure but has limited applicability for unilateral control of symptoms. RF is invasive, and GKRS has unpredictable delayed effects. Each of these surgical modalities has advantages and limitations that need consideration when selecting a treatment for the ET patients.

Indexed as

Deep Brain StimulationEssential TremorHumansRadiosurgeryThalamusTreatment OutcomeDBSdeep brain stimulationEssential tremorETFUSthalamotomy

Identifiers

PMID33081571
PMCPMC13237664

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.