Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives.

Nandor Gyorfi, Emese Farkas, Norbert Nemet, Csaba Weber, Zoltan Novak, Andras Kotschy

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Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Nandor GyorfiServier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.

Emese FarkasServier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.

Norbert NemetServier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.ORCID 0000-0001-6800-1710

Csaba WeberServier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.

Zoltan NovakInstitute of Chemistry, Eötvös Loránd Unversity, Pázmány Péter s. 1/A, H-1117 Budapest, Hungary.

Andras KotschyServier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.ORCID 0000-0002-7675-3864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant

Indexed as

AlkenesCatalysisCopperHydrocarbons, FluorinatedMethylationMolecular StructureAlkenesCopperHydrocarbons, Fluorinatedcopper catalysisheterocyclestrifluoromethylation

Identifiers

PMID33081411

DOI10.3390/molecules25204766

PMCPMC7587554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.