Evidence map›Paper›PMID 33081401›Full record

ReviewCancers2020

Intestinal Microbiota in Colorectal Cancer Surgery.

Ioannis Koliarakis, Elias Athanasakis, Markos Sgantzos, Theodoros Mariolis-Sapsakos, Evangelos Xynos, Emmanuel Chrysos, John Souglakos, John Tsiaoussis

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  17. Postoperative delayed gastric emptying: may gut microbiota play a role?Frontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ioannis KoliarakisLaboratory of Anatomy, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Elias AthanasakisDepartment of General Surgery, University Hospital of Heraklion, 71110 Heraklion, Greece.
Markos SgantzosLaboratory of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.
Theodoros Mariolis-SapsakosSurgical Department, National and Kapodistrian University of Athens, Agioi Anargyroi General and Oncologic Hospital of Kifisia, 14564 Athens, Greece.
Evangelos XynosDepartment of Surgery, Creta Interclinic Hospital of Heraklion, 71305 Heraklion, Greece.
Emmanuel ChrysosDepartment of General Surgery, University Hospital of Heraklion, 71110 Heraklion, Greece.
John SouglakosLaboratory of Translational Oncology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
John TsiaoussisLaboratory of Anatomy, School of Medicine, University of Crete, 70013 Heraklion, Greece.
University of Crete · GRUniversity Hospital of Heraklion · GRNational and Kapodistrian University of Athens · GRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal microbiota consists of numerous microbial species that collectively interact with the host, playing a crucial role in health and disease. Colorectal cancer is well-known to be related to dysbiotic alterations in intestinal microbiota. It is evident that the microbiota is significantly affected by colorectal surgery in combination with the various perioperative interventions, mainly mechanical bowel preparation and antibiotic prophylaxis. The altered postoperative composition of intestinal microbiota could lead to an enhanced virulence, proliferation of pathogens, and diminishment of beneficial microorganisms resulting in severe complications including anastomotic leakage and surgical site infections. Moreover, the intestinal microbiota could be utilized as a possible biomarker in predicting long-term outcomes after surgical CRC treatment. Understanding the underlying mechanisms of these interactions will further support the establishment of genomic mapping of intestinal microbiota in the management of patients undergoing CRC surgery.

Indexed as

anastomotic leakageantibioticsbowel preparationcolorectal cancerdysbiosisintestinal microbiotaoutcomessurgerysurgical site infection

Identifiers

PMID33081401
PMCPMC7602998
OpenAlexW3092921383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.