Evidence map›Paper›PMID 33081386›Full record

ArticleInternational journal of molecular sciences2020

Gene Expression Regulation and Secretory Activity of Mesenchymal Stem Cells upon In Vitro Contact with Microarc Calcium Phosphate Coating.

Larisa Litvinova, Kristina Yurova, Valeria Shupletsova, Olga Khaziakhmatova, Vladimir Malashchenko, Egor Shunkin, Elena Melashchenko, Natalia Todosenko, Marina Khlusova, Yurii Sharkeev and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Larisa LitvinovaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.ORCID 0000-0001-5231-6910
Kristina YurovaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Valeria ShupletsovaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Olga KhaziakhmatovaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Vladimir MalashchenkoCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Egor ShunkinCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Elena MelashchenkoCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Natalia TodosenkoCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.
Marina KhlusovaDepartment of Pathophysiology, Siberian State Medical University, Tomsk 634050, Russia.
Yurii SharkeevLaboratory of Physics of Nanostructured Biocomposites, Institute of Strength Physics and Materials Science, SB RAS, Tomsk 634055, Russia.
Ekaterina KomarovaLaboratory of Physics of Nanostructured Biocomposites, Institute of Strength Physics and Materials Science, SB RAS, Tomsk 634055, Russia.ORCID 0000-0002-0903-6750
Maria SedelnikovaLaboratory of Physics of Nanostructured Biocomposites, Institute of Strength Physics and Materials Science, SB RAS, Tomsk 634055, Russia.
Igor KhlusovCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad 236000, Russia.ORCID 0000-0003-3465-8452
Immanuel Kant Baltic Federal University · RUInstitute of Strength Physics and Materials Science · RUSiberian State Medical University · RU

Funding

Russian Science Foundation 16-15-10031
6 · The paper itself

Abstract

The manufacture of biomaterial surfaces with desired physical and chemical properties that can directly induce osteogenic differentiation without the need for biochemical additives is an excellent strategy for controlling the behavior of mesenchymal stem cells (MSCs) in vivo. We studied the cellular and molecular reactions of MSCs to samples with a double-sided calcium phosphate (CaP) coating and an average roughness index (Ra) of 2.4-4.6 µm. The study aimed to evaluate the effect of a three-dimensional matrix on the relative mRNA expression levels of genes associated with the differentiation and maturation of MSCs toward osteogenesis (

Indexed as

Adipose TissueAdultAlkaline PhosphataseBone Morphogenetic ProteinsCalcium PhosphatesCell DifferentiationCells, CulturedCoated Materials, BiocompatibleCore Binding Factor Alpha 1 SubunitHumansMaleMesenchymal Stem CellsOsteoblastsOsteocalcinAlkaline PhosphataseALPL protein, humanBGLAP protein, humanBone Morphogenetic Proteinscalcium phosphateCalcium PhosphatesCoated Materials, BiocompatibleCore Binding Factor Alpha 1 SubunitOsteocalcinRUNX2 protein, humancorrelationscytokine/chemokine geneshuman adipose tissuemicroarc oxidation techniqueosteogenic genesstem cell culturetechnological coating properties

Identifiers

PMID33081386
PMCPMC7589914
OpenAlexW3092923158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.