Evidence map›Paper›PMID 33081293›Full record

ArticleBiomolecules2020

Suppression of Inflammation Delays Hair Cell Regeneration and Functional Recovery Following Lateral Line Damage in Zebrafish Larvae.

Ru Zhang, Xiaopeng Liu, Yajuan Li, Ming Wang, Lin Chen, Bing Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Hair Cell Regeneration: From Animals to Humans.Clinical and experimental otorhinolaryngology · 2024
    Review
  3. Article
  4. Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types.International journal of environmental research and public health · 2021
    Article
  5. Role of Macrophages and Microglia in Zebrafish Regeneration.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ru ZhangHefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Biomedical Sciences, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0002-6144-8752
Xiaopeng LiuCenter for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0001-9856-0150
Yajuan LiLaboratory of Neurodevelopment and Repair, University of Science and Technology of China, Hefei 230027, China.
Ming WangHefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Biomedical Sciences, University of Science and Technology of China, Hefei 230027, China.
Lin ChenHefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Biomedical Sciences, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0002-5847-2989
Bing HuHefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Biomedical Sciences, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0001-8627-5272
University of Science and Technology of China · CNUniversity at Buffalo, State University of New York · US

Funding

National Natural Science Foundation of China 31771183National Natural Science Foundation of China 81570915National Natural Science Foundation of China 81970886the National Key Research and Development Program of China 2019YFA0405603
6 · The paper itself

Abstract

Cochlear hair cells in human beings cannot regenerate after loss; however, those in fish and other lower species can. Recently, the role of inflammation in hair cell regeneration has been attracting the attention of scientists. In the present study, we investigated how suppression of inflammatory factors affects hair cell regeneration and the functional recovery of regenerated hair cells in zebrafish. We killed hair cells in the lateral line of zebrafish larvae with CuSO

Indexed as

AnimalsCell DeathCell MovementCell ProliferationCopper SulfateHair Cells, VestibularHumansInflammationLarvaLateral Line SystemMacrophagesRegenerationZebrafishCopper Sulfatecalcium imaginghair cell regenerationneuromastrheotaxiszebrafish larva

Identifiers

PMID33081293
PMCPMC7650643
OpenAlexW3092752918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.