Evidence map›Paper›PMID 33081278›Full record

ArticlePharmaceutics2020

Conjugation of Native-Like HIV-1 Envelope Trimers onto Liposomes Using EDC/Sulfo-NHS Chemistry: Requirements and Limitations.

Ehsan Suleiman, Julia Mayer, Elisabeth Lehner, Bianca Kohlhauser, Alexandra Katholnig, Mirjam Batzoni, Dominik Damm, Vladimir Temchura, Andreas Wagner, Klaus Überla and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Modulation of immune responses to liposomal vaccines by intrastructural help.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ehsan SuleimanPolymun Scientific Immunbiologische Forschung GmbH, 3400 Klosterneuburg, Austria.
Julia MayerDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Elisabeth LehnerDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Bianca KohlhauserDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Alexandra KatholnigDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Mirjam BatzoniDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Dominik DammInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Vladimir TemchuraInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Andreas WagnerPolymun Scientific Immunbiologische Forschung GmbH, 3400 Klosterneuburg, Austria.
Klaus ÜberlaInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Karola Vorauer-UhlDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.

Funding

Austrian Science Fund FWF W1224Austrian Science Fund FWF W 1224Horizon 2020 Framework Programme 681137
6 · The paper itself

Abstract

The display of native-like human immunodeficiency virus type 1 envelope (HIV-1 Env) trimers on liposomes has gained wide attention over the last few years. Currently, available methods have enabled the preparation of Env-liposome conjugates of unprecedented quality. However, these protocols require the Env trimer to be tagged and/or to carry a specific functional group. For this reason, we have investigated

Indexed as

covalent conjugationEDC/Sulfo-NHSHIV-1intrastructural helpliposomesnative-like Env trimersparticulate displaypre-concentrationprotein-liposome conjugatestag-free conjugationvaccines

Identifiers

PMID33081278
PMCPMC7589475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.