Evidence map›Paper›PMID 33081247›Full record

ArticleBrain sciences2020

Brain Magnetic Resonance Findings in 117 Children with Autism Spectrum Disorder under 5 Years Old.

Magali Jane Rochat, Giacomo Distefano, Monica Maffei, Francesco Toni, Annio Posar, Maria Cristina Scaduto, Federica Resca, Cinzia Cameli, Elena Bacchelli, Elena Maestrini and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Autism Spectrum Disorder in 2023: A Challenge Still Open.Turkish archives of pediatrics · 2023
    Article
  6. Article
  7. Viruses and autism: A Bi-mutual cause and effect.World journal of virology · 2023
    Review
  8. Article
  9. Article
  10. Structure, Function, and Genetics of the Cerebellum in Autism.Journal of psychiatry and brain science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Magali Jane RochatIRCCS Istituto delle Scienze Neurologiche di Bologna, Diagnostica Funzionale Neuroradiologica, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.
Giacomo DistefanoDipartimento di Medicina Specialistica Diagnostica e Sperimentale (DIMES), Università di Bologna, 40126 Bologna, Italy.
Monica MaffeiIRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuroradiologia, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.
Francesco ToniIRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuroradiologia, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.
Annio PosarIRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-5024-4578
Maria Cristina ScadutoIRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.
Federica RescaIRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.
Cinzia CameliDipartimento di Farmacia e Biotecnologie, Università di Bologna, 40126 Bologna, Italy.
Elena BacchelliDipartimento di Farmacia e Biotecnologie, Università di Bologna, 40126 Bologna, Italy.ORCID 0000-0001-8800-9568
Elena MaestriniDipartimento di Farmacia e Biotecnologie, Università di Bologna, 40126 Bologna, Italy.
Paola ViscontiIRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Ospedale Bellaria di Bologna, 40139 Bologna, Italy.
Istituto delle Scienze Neurologiche di Bologna · ITUniversity of Bologna · IT

Funding

Italian Ministry of Health Bando Ricerca Finalizzata, Prot. GR-2013-02357561
6 · The paper itself

Abstract

We examined the potential benefits of neuroimaging measurements across the first 5 years of life in detecting early comorbid or etiological signs of autism spectrum disorder (ASD). In particular, we analyzed the prevalence of neuroradiologic findings in routine magnetic resonance imaging (MRI) scans of a group of 117 ASD children younger than 5 years old. These data were compared to those reported in typically developing (TD) children. MRI findings in children with ASD were analyzed in relation to their cognitive level, severity of autistic symptoms, and the presence of electroencephalogram (EEG) abnormalities. The MRI was rated abnormal in 55% of children with ASD with a significant prevalence in the high-functioning subgroup compared to TD children. We report significant incidental findings of mega cisterna magna, ventricular anomalies and abnormal white matter signal intensity in ASD without significant associations between these MRI findings and EEG features. Based on these results we discuss the role that brain MRI may play in the diagnostic procedure of ASD.

Indexed as

autism spectrum disorderincidental findingsmagnetic resonance imagingneurobiology

Identifiers

PMID33081247
PMCPMC7602717
OpenAlexW3092752125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.