Evidence map›Paper›PMID 33081105›Full record

ArticleNutrients2020

Transport of a Peptide from Bovine α

Brian Christensen, Andrea E Toth, Simone S E Nielsen, Carsten Scavenius, Steen V Petersen, Jan J Enghild, Jan T Rasmussen, Morten S Nielsen, Esben S Sørensen

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Brian ChristensenDepartment of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
Andrea E TothDepartment of Biomedicine, Faculty of Health, Aarhus University, DK-8000 Aarhus, Denmark.ORCID 0000-0001-6122-919X
Simone S E NielsenDepartment of Biomedicine, Faculty of Health, Aarhus University, DK-8000 Aarhus, Denmark.
Carsten ScaveniusDepartment of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
Steen V PetersenDepartment of Biomedicine, Faculty of Health, Aarhus University, DK-8000 Aarhus, Denmark.
Jan J EnghildDepartment of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
Jan T RasmussenDepartment of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
Morten S NielsenDepartment of Biomedicine, Faculty of Health, Aarhus University, DK-8000 Aarhus, Denmark.
Esben S SørensenDepartment of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.ORCID 0000-0002-7050-3354
Aarhus University · DK

Funding

Arla Foods Ingredients Group P/S, Viby J, Denmark #Danish Dairy Research Foundation, Aarhus N, Denmark #
6 · The paper itself

Abstract

The effect of food components on brain growth and development has attracted increasing attention. Milk has been shown to contain peptides that deliver important signals to the brains of neonates and infants. In order to reach the brain, milk peptides have to resist proteolytic degradation in the gastrointestinal tract, cross the gastrointestinal barrier and later cross the highly selective blood-brain barrier (BBB). To investigate this, we purified and characterized endogenous peptides from bovine milk and investigated their apical to basal transport by using human intestinal Caco-2 cells and primary porcine brain endothelial cell monolayer models. Among 192 characterized milk peptides, only the α

Indexed as

AnimalsBiological TransportBlood-Brain BarrierBrainCaco-2 CellsCaseinsCattleEndothelial CellsHumansIntestinal MucosaMilkPeptidesSwineCaseinsPeptidesblood–brain barrierCaco-2 cellsgastrointestinal digestionmilk peptidespeptide transport

Identifiers

PMID33081105
PMCPMC7602804
OpenAlexW3093402586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.