Evidence map›Paper›PMID 33081101›Full record

ArticleInternational journal of molecular sciences2020

Nitroxides Mitigate Neutrophil-Mediated Damage to the Myocardium after Experimental Myocardial Infarction in Rats.

Mary El Kazzi, Han Shi, Sally Vuong, Xiaosuo Wang, Belal Chami, Yuyang Liu, Benjamin S Rayner, Paul K Witting

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Myeloperoxidase in Health and Disease.International journal of molecular sciences · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mary El KazziDiscipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney 2006 NSW, Australia.
Han ShiDiscipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney 2006 NSW, Australia.
Sally VuongHeart Research Institute, Sydney Medical School, The University of Sydney, Sydney 2006 NSW, Australia.ORCID 0000-0003-2295-7893
Xiaosuo WangDiscipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney 2006 NSW, Australia.
Belal ChamiDiscipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney 2006 NSW, Australia.
Yuyang LiuDiscipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney 2006 NSW, Australia.
Benjamin S RaynerHeart Research Institute, Sydney Medical School, The University of Sydney, Sydney 2006 NSW, Australia.ORCID 0000-0002-3446-2241
Paul K WittingDiscipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney 2006 NSW, Australia.ORCID 0000-0003-2237-7004
The University of Sydney · AU

Funding

CSIRO SIEF STEM+ Business FellowshipNational Health and Medical Research Council 1125392
6 · The paper itself

Abstract

Reperfusion therapy increases survival post-acute myocardial infarction (AMI) while also stimulating secondary oxidant production and immune cell infiltration. Neutrophils accumulate within infarcted myocardium within 24 h post-AMI and release myeloperoxidase (MPO) that catalyses hypochlorous acid (HOCl) production while increasing oxidative stress and inflammation, thereby enhancing ventricular remodelling. Nitroxides inhibit MPO-mediated HOCl production, potentially ameliorating neutrophil-mediated damage.

Indexed as

AnimalsCardiotonic AgentsHypochlorous AcidMaleMyocardial InfarctionMyocardiumNeutrophilsNF-kappa BOxidative StressPeroxidasePiperidinesRatsRats, WistarTumor Necrosis Factor-alphaTyrosine2,2,6,6-tetramethyl-1-piperidine3-chlorotyrosineCardiotonic AgentsHypochlorous AcidNF-kappa BPeroxidasePiperidinesTumor Necrosis Factor-alphaTyrosinecardiac damageheart attackhost damageneutrophil

Identifiers

PMID33081101
PMCPMC7589606
OpenAlexW3092692328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.