Evidence map›Paper›PMID 33081006›Full record

ArticleBiomedicines2020

Rheological Properties and Growth Factors Content of Platelet-Rich Plasma: Relevance in Veterinary Biomedical Treatments.

Diego Romano Perinelli, Giulia Bonacucina, Stefania Pucciarelli, Marco Cespi, Evelina Serri, Valeria Polzonetti, Adolfo Maria Tambella, Silvia Vincenzetti

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Diego Romano PerinelliSchool of Pharmacy, University of Camerino, 62032 Camerino (MC), Italy.ORCID 0000-0002-7686-4150
Giulia BonacucinaSchool of Pharmacy, University of Camerino, 62032 Camerino (MC), Italy.
Stefania PucciarelliSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino (MC), Italy.ORCID 0000-0003-2137-5517
Marco CespiSchool of Pharmacy, University of Camerino, 62032 Camerino (MC), Italy.ORCID 0000-0001-6916-7915
Evelina SerriSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino (MC), Italy.
Valeria PolzonettiSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino (MC), Italy.ORCID 0000-0003-2674-9039
Adolfo Maria TambellaSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino (MC), Italy.ORCID 0000-0002-6590-1876
Silvia VincenzettiSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino (MC), Italy.ORCID 0000-0002-6386-5437
Università di Camerino · IT

Funding

Università degli Studi di Camerino Fondo di Ateneo per la Ricerca 2014.2015
6 · The paper itself

Abstract

Platelet-rich plasma (PRP) is a nontransfusional hemocomponent, considered as a powerful concentrate of growth factors (GFs) therapeutically used to stimulate tissue regeneration. The use of autologous PRP, as the patient's own biological material, for therapeutic purposes represents a safe and effective alternative to conventional treatments in both human and veterinary medicine. The aim of this study was the characterization of canine PRP from rheological and biological points of view. Thus, a characterization of the viscoelastic properties of the PRP systems was performed in order to clarify the influence of different calcium concentrations, in the presence of autologous thrombin-rich solution, on the PRP gels' mechanical properties, from which the applicability of these systems in biomedical treatments is strongly dependent. Then, an evaluation of the content of GFs in PRP, activated or not with thrombin, and stored at different temperatures (37 °C and -20 °C) was performed over time, outlining, for the first time, the importance of the effect of physiological temperature (37 °C) on the production of GFs. A clinical case study conducted in a dog with a complete rupture of the common calcaneal tendon (Achilles tendon) confirmed the relevance of this hemocomponent in the daily veterinary clinical activity and the potential translational value for human health.

Indexed as

ELISA testHemocomponentPRP gelsstorage stabilitythrombin-rich solutionviscoelastic properties

Identifiers

PMID33081006
PMCPMC7603199
OpenAlexW3093463256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.