Evidence map›Paper›PMID 33080397›Full record

ArticleJournal of biomedical informatics2020

A secure system for genomics clinical decision support.

Seemeen Karimi, Xiaoqian Jiang, Robert H Dolin, Miran Kim, Aziz Boxwala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical informatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seemeen KarimiElimu Informatics Inc., Richmond, CA, United States. Electronic address: seemeen.karimi@elimu.io.
Xiaoqian JiangUT Health School of Biomedical Informatics, Houston, TX, United States.
Robert H DolinElimu Informatics Inc., Richmond, CA, United States.
Miran KimUT Health School of Biomedical Informatics, Houston, TX, United States.
Aziz BoxwalaElimu Informatics Inc., Richmond, CA, United States.

Funding

Secure outsourced computation of genomic dataR41HG010978 · NHGRI · ELIMU INFORMATICS, INC. · PI BOXWALA, AZIZ A, KIM, MIRAN · 2019 to 2020
$566k
Reliable Performance of Cancer Screening using a Computer-based Monitoring SystemR43CA134042 · NCI · U.S. CARELINK · PI BOXWALA, AZIZ A · 2008 to 2008
$123k
NCI NIH HHS R43 CA134042NHGRI NIH HHS R41 HG010978
6 · The paper itself

Abstract

We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions.

Indexed as

Decision Support Systems, ClinicalComputer SecurityGenome-Wide Association StudyGenomicsHumansPrivacyGenome archiving and communications systemGenomic computationHomomorphic encryptionSecure clinical decision supportSecure outsourcing

Identifiers

PMID33080397
PMCPMC8577277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.