Evidence map›Paper›PMID 33080269›Full record

ArticleMetabolism: clinical and experimental2021

Commentary: COVID-19 and obesity pandemics converge into a syndemic requiring urgent and multidisciplinary action.

Michael A Hill, James R Sowers, Christos S Mantzoros

Abstract read
In one paragraph

Article in Metabolism: clinical and experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  7. Editorial: Obesity, metabolic phenotypes and COVID-19.Metabolism: clinical and experimental · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael A HillDalton Cardiovascular Center, Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, United States of America. Electronic address: hillmi@missouri.edu.
James R SowersDalton Cardiovascular Center, Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, United States of America.
Christos S MantzorosDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, The Section of Endocrinology, VA Boston Healthcare System and Harvard Medical School, Boston, MA, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While substantial evidence points towards obesity and associated cardiometabolic disorders being a major factor for poor outcomes in SARS-CoV2 infections (COVID-19), the complexity of the interplay between these two pandemics is becoming apparent. Indeed, as previously defined, this interaction between obesity and COVID-19 represents a 'syndemic' that requires both current and ongoing attention. At a mechanistic level the chronic inflammatory environment of obesity predisposes to life threatening events such as cytokine storm and enhanced coagulopathy. Obesity and its management are affected by diverse factors manifested at societal, educational, racial, and nutritional levels. A multidisciplinary approach is required to manage obese and type 2 diabetic patients, not only during the current COVID-19 crisis, but to decrease the growing burden of cardiometabolic disease and associated cardiovascular complications impacting future viral pandemics. Further, this syndemic has highlighted disparities in healthcare which need to be addressed to achieve equality in health outcomes in patients infected with COVID-19.

Indexed as

SyndemicCOVID-19HumansObesityPandemicsSARS-CoV-2

Identifiers

PMID33080269
PMCPMC7831812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.