ArticleNeurosurgery2021
Alterations in Functional Connectomics Associated With Neurocognitive Changes Following Glioma Resection.
Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Influences on cognitive outcomes in adult patients with gliomas: A systematic review.Frontiers in oncology · 2022Pooled it
- Application of multidimensional cognitive training in the early postoperative period for glioma patients with cognitive impairment.Journal of neuro-oncology · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Neuropsychological outcomes following awake surgery in adult glioma patients: A systematic review.Neuro-oncology practice · 2026Article
- Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients.Frontiers in neuroscience · 2026Article
- Experimental Evaluation of QY-69: A Butyrylcholinesterase Inhibitor with Anti-Glioblastoma Efficacy.Current neuropharmacology · 2026Article
- Predicting attention deficits and functional recovery after glioma resection through functional executive networks: insights from dynamic properties.Journal of neuro-oncology · 2025Article
- Review
- Tumor resting-state fMRI connectivity to extralesional brain is associated with cognitive performance in glioma patients.Brain & spine · 2025Article
- Pseudo-Resting-State Functional MRI Derived from Dynamic Susceptibility Contrast Perfusion MRI Can Predict Cognitive Impairment in Glioma.AJNR. American journal of neuroradiology · 2024Article
- Neural Influences on Tumor Progression Within the Central Nervous System.CNS neuroscience & therapeutics · 2024Review
- Perioperative Neurocognitive Function in Glioma Surgery.Current oncology reports · 2024Review
- Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.Brain imaging and behavior · 2023Article
- The longitudinal relation between executive functioning and multilayer network topology in glioma patients.Brain imaging and behavior · 2023Article
- Characterization of cognitive function in survivors of diffuse gliomas using resting-state functional MRI (rs-fMRI).Brain imaging and behavior · 2022Article
- What Can Resting-State fMRI Data Analysis Explain about the Functional Brain Connectivity in Glioma Patients?Tomography (Ann Arbor, Mich.) · 2022Review
- Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours.Clinical and translational radiation oncology · 2021Article
- Perioperative neurocognitive functioning in elderly patients undergoing awake craniotomy for high grade glioma.Neuro-oncology advancesArticle
- Changes in functional connectivity are associated with functional independence in the early postoperative period following awake surgical resection of language-eloquent glioma.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDecline in neurocognitive functioning (NCF) often occurs following brain tumor resection. Functional connectomics have shown how neurologic insults disrupt cerebral networks underlying NCF, though studies involving patients with brain tumors are lacking.
objectiveTo investigate the impact of brain tumor resection upon the connectome and relationships with NCF outcome in the early postoperative period.
methodsA total of 15 right-handed adults with left perisylvian glioma underwent resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological assessment before and after awake tumor resection. Graph theoretical analysis was applied to rs-fMRI connectivity matrices to calculate network properties. Network properties and NCF measures were compared across the pre- to postoperative periods with matched pairs Wilcoxon signed-rank tests. Associations between pre- to postoperative change in network and NCF measures were determined with Spearman rank-order correlations (ρ).
resultsA majority of the sample showed postoperative decline on 1 or more NCF measures. Significant postoperative NCF decline was found across measures of verbal memory, processing speed, executive functioning, receptive language, and a composite index. Regarding connectomic properties, betweenness centrality and assortativity were significantly smaller postoperatively, and reductions in these measures were associated with better NCF outcomes. Significant inverse associations (ρ = -.51 to -.78, all P < .05) were observed between change in language, executive functioning, and learning and memory, and alterations in segregation, centrality, and resilience network properties.
conclusionDecline in NCF was common shortly following resection of glioma involving eloquent brain regions, most frequently in verbal learning/memory and executive functioning. Better postoperative outcomes accompanied reductions in centrality and resilience connectomic measures.
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Registered trials
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