Evidence map›Paper›PMID 33079621›Full record

SynthesisEpigenetics

Birth weight associations with DNA methylation differences in an adult population.

Rebecca A Madden, Daniel L McCartney, Rosie M Walker, Robert F Hillary, Mairead L Bermingham, Konrad Rawlik, Stewart W Morris, Archie Campbell, David J Porteous, Ian J Deary and 4 more

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Epigenetics of Childhood Obesity.Hormone research in paediatrics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Rebecca A MaddenDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.ORCID 0000-0003-1617-3822
Daniel L McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-3242-0360
Rosie M WalkerCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-1060-4479
Robert F HillaryCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2595-552X
Mairead L BerminghamCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0931-0051
Konrad RawlikThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.ORCID 0000-0002-0010-370X
Stewart W MorrisCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-0198-5078
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-1249-6106
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-1733-263X
Kathryn L EvansCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-7884-5877
Jonathan HaffertyDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.ORCID 0000-0003-3060-6436
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.ORCID 0000-0002-0198-4588
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4430-4260
University of Edinburgh · GBRoyal Edinburgh Hospital · GBRoslin Institute · GB

Funding

Medical Research Council MC_PC_17209Medical Research Council MR/J000914/1Medical Research Council MR/K026992/1MRF_ C0396Wellcome Trust
6 · The paper itself

Abstract

The Developmental Origins of Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience and has been associated with multiple adult health outcomes. DNA methylation (DNAm) is one plausible mechanism behind the relationship of birth weight to adult health. Through data linkage between Generation Scotland and historic Scottish birth cohorts, and birth records held through the NHS Information and Statistics Division, a sample of 1,757 individuals with available birth weight and DNAm data was derived. Epigenome-wide association studies (EWAS) were performed in two independently generated DNAm subgroups (n

Indexed as

Birth CohortDNA MethylationAdultBirth WeightEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansPregnancybirth weightdepressionDNA methylationEWASGeneration Scotland

Identifiers

PMID33079621
PMCPMC8216207
OpenAlexW3043709389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.