Evidence map›Paper›PMID 33079572›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults.

Kara J Mould, Camille M Moore, Shannon A McManus, Alexandra L McCubbrey, Jazalle D McClendon, Christine L Griesmer, Peter M Henson, William J Janssen

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 137 citations in OpenAlex.

  1. Trial
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  3. Alternative splicing of toll-like receptor pathway mRNAs in lung immune cells from patients with ARDS.American journal of physiology. Lung cellular and molecular physiology · 2026
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  13. Tissue signatures of human macrophages during homeostasis and activation.Journal of immunology (Baltimore, Md. : 1950) · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kara J MouldDepartment of Medicine.ORCID 0000-0003-2967-2778
Camille M MooreDepartment of Pediatrics, National Jewish Health, Denver, Colorado.
Shannon A McManusDepartment of Medicine.
Alexandra L McCubbreyDepartment of Medicine.
Jazalle D McClendonDepartment of Medicine.
Christine L GriesmerDepartment of Medicine.
Peter M HensonDepartment of Biomedical Research, and.
William J JanssenDepartment of Medicine.
National Jewish Health · USUniversity of Colorado Denver · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Lung Macrophage Programming in Acute Lung InjuryR35HL140039 · NHLBI · NATIONAL JEWISH HEALTH · PI JANSSEN, WILLIAM · 2018 to 2024
$6.4M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
Neutrophil Nox2 controls mononuclear cell functions in inflammation; role in CGDR01AI141389 · NIAID · NATIONAL JEWISH HEALTH · PI BRATTON, DONNA L, HENSON, PETER M · 2018 to 2022
$3.1M
Roles for interstitial and airspace macrophages in resolution of pulmonary inflammationR01HL149741 · NHLBI · NATIONAL JEWISH HEALTH · PI HENSON, PETER M, REDENTE, ELIZABETH FRANCES · 2020 to 2023
$3.0M
Temporal regulation of pulmonary inflammation by MyD88 alternative pre-mRNA splicingR01HL148335 · NHLBI · NATIONAL JEWISH HEALTH · PI ALPER, SCOTT · 2019 to 2022
$2.3M
Metabolic Reprogramming of Recruited Alveolar Macrophages by Arginine In Acute Lung InjuryK08HL141648 · NHLBI · NATIONAL JEWISH HEALTH · PI MOULD, KARA J · 2018 to 2022
$798k
Macrophage Metabolism After Target Cell Ingestion Regulates Anti-Inflammatory ReprogrammingK99HL141658 · NHLBI · NATIONAL JEWISH HEALTH · PI MCCUBBREY, ALEXANDRA LEIGH · 2018 to 2019
$312k
NCI NIH HHS P30 CA046934NHLBI NIH HHS K08 HL141648NHLBI NIH HHS K99 HL141658NHLBI NIH HHS R01 HL130938NHLBI NIH HHS R01 HL148335NHLBI NIH HHS R01 HL149741NHLBI NIH HHS R35 HL140039NIAID NIH HHS R01 AI141389
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression ProfilingSequence Analysis, RNAAdultBronchoalveolar Lavage FluidFemaleHealthy VolunteersHumansLeukocytes, MononuclearMacrophages, AlveolarMaleMiddle AgedMonocytesPulmonary AlveoliSex Factorsalveolar macrophagesbronchoalveolar lavageRNA sequencing

Identifiers

PMID33079572
PMCPMC8048748
OpenAlexW3094122586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.