Evidence map›Paper›PMID 33079327›Full record

ReviewMagma (New York, N.Y.)2021

15 Years MR-encephalography.

Juergen Hennig, Vesa Kiviniemi, Bruno Riemenschneider, Antonia Barghoorn, Burak Akin, Fei Wang, Pierre LeVan

Open access · hybridAbstract readReview
In one paragraph

Review in Magma (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Article
  3. Sleep Alters the Velocity of Physiological Brain Pulsations in Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Delta Wave MRI: fMRI of Electrophysiologic Activity.AJNR. American journal of neuroradiology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Juergen HennigDepartment of Radiology, Medical Physics, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany. Juergen.hennig@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-2273-3497
Vesa KiviniemiOulu Functional NeuroImaging Group, Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.
Bruno RiemenschneiderDepartment of Radiology, Center for Biomedical Imaging, New York University Grossman School of Medicine, New York, NY, USA.
Antonia BarghoornDepartment of Radiology, Medical Physics, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
Burak AkinDepartment of Radiology, Medical Physics, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
Fei WangDepartment of Radiology, Medical Physics, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
Pierre LeVanDepartments of Radiology and Paediatrics, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
University of Freiburg · DENew York University · USUniversity of Calgary · CAUniversity of Oulu · FI

Funding

Academy of Finland 275352Academy of Finland 314497Bundesministerium für Bildung und Forschung 01EQ0605Bundesministerium für Bildung und Forschung INUMAC, 13N9208Deutsche Forschungsgemeinschaft Cluster of Excellence EXC1086Deutsche Forschungsgemeinschaft Rein-Hard-Kosselleck-Grant He 1875/28-1H2020 European Research Council 232908
6 · The paper itself

Abstract

objectiveThis review article gives an account of the development of the MR-encephalography (MREG) method, which started as a mere 'Gedankenexperiment' in 2005 and gradually developed into a method for ultrafast measurement of physiological activities in the brain. After going through different approaches covering k-space with radial, rosette, and concentric shell trajectories we have settled on a stack-of-spiral trajectory, which allows full brain coverage with (nominal) 3 mm isotropic resolution in 100 ms. The very high acceleration factor is facilitated by the near-isotropic k-space coverage, which allows high acceleration in all three spatial dimensions.

methodsThe methodological section covers the basic sequence design as well as recent advances in image reconstruction including the targeted reconstruction, which allows real-time feedback applications, and-most recently-the time-domain principal component reconstruction (tPCR), which applies a principal component analysis of the acquired time domain data as a sparsifying transformation to improve reconstruction speed as well as quality. APPLICATIONS: Although the BOLD-response is rather slow, the high speed acquisition of MREG allows separation of BOLD-effects from cardiac and breathing related pulsatility. The increased sensitivity enables direct detection of the dynamic variability of resting state networks as well as localization of single interictal events in epilepsy patients. A separate and highly intriguing application is aimed at the investigation of the glymphatic system by assessment of the spatiotemporal patterns of cardiac and breathing related pulsatility. DISCUSSION: MREG has been developed to push the speed limits of fMRI. Compared to multiband-EPI this allows considerably faster acquisition at the cost of reduced image quality and spatial resolution.

Indexed as

Brain MappingBrainEpilepsyHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPrincipal Component AnalysisFunctional magnetic resonance imagingMagnetic resonance imaging

Identifiers

PMID33079327
PMCPMC7910380
OpenAlexW3093425840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.