Evidence map›Paper›PMID 33079324›Full record

ArticleNeurochemical research2020

Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases.

Cindy Juliet Cristancho Ortiz, Caio Miranda Damasio, Letizia Pruccoli, Nathália Fonseca Nadur, Luciana Luiza de Azevedo, Isabella Alvim Guedes, Laurent Emmanuel Dardenne, Arthur Eugen Kümmerle, Andrea Tarozzi, Claudio Viegas

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In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Cindy Juliet Cristancho OrtizPeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, Jovino Fernandes Sales Avenue 2600, Alfenas, MG, 37130-840, Brazil.
Caio Miranda DamasioPeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, Jovino Fernandes Sales Avenue 2600, Alfenas, MG, 37130-840, Brazil.
Letizia PruccoliDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921, Rimini, Italy.
Nathália Fonseca NadurLaboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio De Janeiro, RJ, 21941-902, Brazil.
Luciana Luiza de AzevedoLaboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio De Janeiro, RJ, 21941-902, Brazil.
Isabella Alvim GuedesNational Laboratory of Scientific Computation, Petrópolis, RJ, 25651-075, Brazil.
Laurent Emmanuel DardenneNational Laboratory of Scientific Computation, Petrópolis, RJ, 25651-075, Brazil.
Arthur Eugen KümmerleLaboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio De Janeiro, RJ, 21941-902, Brazil.
Andrea TarozziDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921, Rimini, Italy. andrea.tarozzi@unibo.it.
Claudio ViegasPeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, Jovino Fernandes Sales Avenue 2600, Alfenas, MG, 37130-840, Brazil. cvjviegas@gmail.com.ORCID http://orcid.org/0000-0002-7799-992X
Universidade Federal de Alfenas · BRUniversidade Federal do Rio de Janeiro · BRLaboratório Nacional de Computação Científica · BRUniversity of Bologna · IT

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #400271/2014-1Conselho Nacional de Desenvolvimento Científico e Tecnológico #454088/2014-0Conselho Nacional de Desenvolvimento Científico e Tecnológico #465.249/2014-0Fundação de Amparo à Pesquisa do Estado de Minas Gerais (#CEX-APQ-00241-15Instituto Nacional de Ciência e Tecnologia da Criosfera #310082/2016-1
6 · The paper itself

Abstract

A new series of ten multifunctional Cinnamoyl-N-acylhydrazone-donepezil hybrids was synthesized and evaluated as multifunctional ligands against neurodegenerative diseases. The molecular hybridization approach was based on the combination of 1-benzyl-4-piperidine fragment from the anti-Alzheimer AChE inhibitor donepezil (1) and the cinnamoyl subunit from curcumin (2), a natural product with remarkable antioxidant, neuroprotective and anti-inflammatory properties, using a N-acylhydrazone fragment as a spacer subunit. Compounds 4a and 4d showed moderate inhibitory activity towards AChE with IC

Indexed as

AcetylcholinesteraseButyrylcholinesteraseCell Line, TumorCholinesterase InhibitorsCinnamatesDonepezilFree Radical ScavengersHumansHydrazonesLigandsMolecular Docking SimulationMolecular StructureNeurodegenerative DiseasesNeuroprotective AgentsProtein BindingStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsCinnamatesDonepezilFree Radical ScavengersHydrazonesLigandsNeuroprotective AgentsCinnamoyl-N-acylhydrazone-donepezil hybrids MTDLsMolecular hybridizationMultifunctional ligandsNeurodegenerative diseases

Identifiers

PMID33079324
OpenAlexW3092734339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.