ArticleInternational journal of clinical oncology2021
Association between the baseline frailty and quality of life in patients with prostate cancer (FRAQ-PC study).
Article in International journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- The Clinical Frailty Scale (CFS) employment in the frailty assessment of patients suffering from Non-Communicable Diseases (NCDs): A systematic review.Frontiers in medicine · 2022Pooled it
- Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial.Integrative cancer therapiesTrial
- Incidence and influencing factors of postoperative frailty in elderly prostate cancer patients: a cross-sectional study.Frontiers in medicine · 2025Article
- Pretreatment Patient-reported Overall Health: A Prognostic Factor for Early Overall Mortality After Primary Curative Treatment of Prostate Cancer.European urology open science · 2024Article
- Frailty of Prostate Cancer Patients Receiving Androgen Deprivation Therapy: A Scoping Review.The world journal of men's health · 2024Article
- Plasma Androstenedione Concentration Can Discriminate Frail versus Non-Frail Men with Prostate Cancer under Androgen Deprivation Therapy.Biomolecules · 2023Article
- Frailty Assessed by the Clinical Frailty Scale is Associated with Prognosis After Esophagectomy.Annals of surgical oncology · 2023Article
- Comparison of Frailty Criteria, Cognitive Function, Depressive and Insomnia Symptoms in Men with Localized and Advanced Prostate Cancer under Androgen Deprivation Therapy.Healthcare (Basel, Switzerland) · 2023Article
- Analysis of Frailty Syndrome in Men with Metastatic Prostate Cancer: A Scoping Review.Journal of personalized medicine · 2023Article
- Real-world outcomes and risk stratification in patients with metastatic castration-sensitive prostate cancer treated with upfront abiraterone acetate and docetaxel.International journal of clinical oncology · 2022Article
- Frailty and its association with health-related quality of life among older cancer patients: an evidence-based study from China.Health and quality of life outcomes · 2022Article
- Elastic tubes: the ideal equipment for telehealth exercise medicine in the management of prostate cancer?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Frailty among inpatients with Schizophrenia: Status, influencing factors, and their correlation with quality of life.Frontiers in psychiatry · 2022Article
- Frailty is associated with poor prognosis after resection for pancreatic cancer.International journal of clinical oncology · 2021Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe association between baseline frailty and health-related quality of life (HRQOL) in patients with prostate cancer (PC) remains unknown.
methodsWe retrospectively evaluated the association of pretreatment frailty with HRQOL in 409 patients with PC from February 2017 to April 2020. Frailty and HRQOL were evaluated using the geriatric 8 (G8) screening tool and QLQ-C30 questionnaire, respectively. The primary objective was comparison of G8 and QOL scores between the localized diseases (M0 group) and metastatic castration-sensitive PC (mCSPC group). Secondary objectives were to study the association of G8 and QOL scores in each group and effect of frailty (G8 ≤ 14) on worse QOL.
resultsThe median age of patients was 70 years. There were 369 (surgery: 196, radiotherapy: 156, androgen deprivation therapy alone: 17) patients in the M0 and 40 patients in the mCSPC groups. There was a significant difference between the M0 and mCSPC groups in the G8 score (14.5 vs. 12.5), functioning QOL (94 vs. 87), global QOL (75 vs. 58), and 100-symptom QOL (94 vs. 85) scores. G8 scores were significantly associated with functioning, global, and 100-symptom QOL scores in both M0 and mCSPC groups. The multivariable logistic regression analyses showed that frailty (G8 ≤ 14) was significantly associated with worse global QOL, functioning QOL, and 100-symptom QOL scores.
conclusionThe baseline frailty and HRQOL were significantly different between the localized and metastatic disease. The baseline frailty was significantly associated with worse HRQOL in patients with PC.
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