Evidence map›Paper›PMID 33079244›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2020

Mitochondria-targeted Re(I) complexes bearing guanidinium as ligands and their anticancer activity.

Shu-Fen He, Nan-Lian Pan, Bing-Bing Chen, Jia-Xin Liao, Min-Ying Huang, Hai-Jun Qiu, Dong-Chun Jiang, Jun-Jie Wang, Jia-Xi Chen, Jing Sun

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Pyrenyl-Substituted Imidazo[4,5-Inorganic chemistry · 2023
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shu-Fen He *School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Nan-Lian Pan *School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Bing-Bing ChenSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Jia-Xin LiaoSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Min-Ying HuangSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Hai-Jun QiuSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Dong-Chun JiangSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Jun-Jie WangSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Jia-Xi ChenSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China. cppcc@qq.com.
Jing SunSchool of Pharmacy, Guangdong Medical University, Dongguan, 523808, China. sunjing@gdmu.edu.cn.
Guangdong Medical College · CNDongguan People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the "powerhouse" of a cell, mitochondria maintain energy homeostasis, synthesize ATP via oxidative phosphorylation, generate ROS signaling molecules, and modulate cell apoptosis. Herein, three Re(I) complexes bearing guanidinium derivatives have been synthesized and characterized. All of these complexes exhibit moderate anticancer activity in HepG2, HeLa, MCF-7, and A549 cancer cells. Mechanism studies indicate that complex 3, [Re(CO)3(L)(Im)](PF

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell MovementCell ProliferationCoordination ComplexesGuanidineHumansLigandsMitochondriaNeoplasm InvasivenessRheniumStructure-Activity RelationshipAntineoplastic AgentsCoordination ComplexesGuanidineLigandsRheniumApoptosisCytotoxicityMitochondriaRe(I) complex

Identifiers

PMID33079244
OpenAlexW3093139867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.