ArticleEmerging infectious diseases2020
Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans.
Article in Emerging infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Resistance to clinically important antibiotics and reduced susceptibility to disinfectants in the pandemic ST398 methicillin-susceptibleFrontiers in microbiology · 2026Article
- Review
- Characterization of the virulence shaping and adaptability in the methicillin-resistantmSystems · 2025Article
- Antibiotic susceptibility and molecular characterization based on whole-genome sequencing of Staphylococcus aureus causing invasive infection in children and women living in Southwest China during 2018-2023.BMC microbiology · 2025Article
- Pathogenomic profile and clonal diversity of potential zoonotic MRSA-CC7-ST789-t091-SCCmecV from human skin and soft tissue infections.Scientific reports · 2024Article
- Genomic analysis ofiScience · 2024Article
- CI:Mor interactions in the lysogeny switches ofMicrobiome research reports · 2024Article
- Genomic Insights into Methicillin-Resistant Staphylococci and Mammaliicocci from Bulk Tank Milk of Dairy Farms in Serbia.Antibiotics (Basel, Switzerland) · 2023Article
- Multi-host infection and phylogenetically diverse lineages shape the recombination and gene pool dynamics of Staphylococcus aureus.BMC microbiology · 2023Article
- Common antibiotics, azithromycin and amoxicillin, affect gut metagenomics within a household.BMC microbiology · 2023Article
- Genomic epidemiology and characterization ofFrontiers in microbiology · 2023Article
- Fluoroquinolone resistance does not facilitate phage Φ13 integration or excision inAccess microbiology · 2023Article
- Prophage-encoded immune evasion factors are critical forCell genomics · 2022Article
- Technical specifications for a baseline survey on the prevalence of methicillin-resistantEFSA journal. European Food Safety Authority · 2022Article
- Bioinformatic Analysis of a Set of 14 Temperate Bacteriophages Isolated from Staphylococcus aureus Strains Highlights Their Massive Genetic Diversity.Microbiology spectrum · 2022Article
- Horizontal transfer and phylogenetic distribution of the immune evasion factorFrontiers in microbiology · 2022Article
- Article
- TheGenes · 2021Review
- The Dissemination and Molecular Characterization of Clonal Complex 361 (CC361) Methicillin-ResistantFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) can acquire phage-encoded immune modulators, such as the immune evasion cluster (IEC), which protects bacteria from components of the human innate immune system, and the enzyme TarP, which protects against antibody-mediated immune recognition. We used whole-genome sequencing and epidemiologic investigations to study the effects of IEC- and tarP-harboring phages on household transmission of LA-MRSA in North Denmark Region during 2004-2011. We reviewed information about all patients throughout Denmark who experienced LA-MRSA infection during 2007-2018 to determine whether IEC is associated with increased spread into the general population. Horizontal acquisition of IEC in the human host was associated with increased household transmission of LA-MRSA and spillover into the community and healthcare settings, whereas we found no evidence to suggest that IEC-positive LA-MRSA isolates have become self-sustainable in the general population. By contrast, TarP did not seem to influence household transmission of LA-MRSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.