Evidence map›Paper›PMID 33078931›Full record

ArticleACS chemical biology2020

Facile Synthesis and Metabolic Incorporation of

Alexis J Apostolos, Julia M Nelson, José Rogério A Silva, Jerônimo Lameira, Alecia M Achimovich, Andreas Gahlmann, Cláudio N Alves, Marcos M Pires

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Activity Profiling of Mycobacterial L,D-Transpeptidases.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Chemical science · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Synthesis of Conformationally Constrained d-Glu-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Alexis J ApostolosDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Julia M NelsonDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
José Rogério A SilvaLaboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais Universidade Federal do Pará, Belém, Pará 66075-110, Brazil.ORCID 0000-0003-2310-5107
Jerônimo LameiraLaboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais Universidade Federal do Pará, Belém, Pará 66075-110, Brazil.ORCID 0000-0001-7270-1517
Alecia M AchimovichDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Andreas GahlmannDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Cláudio N AlvesLaboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais Universidade Federal do Pará, Belém, Pará 66075-110, Brazil.ORCID 0000-0001-6576-4229
Marcos M PiresDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0002-5676-0725
University of Virginia · USUniversidade Federal do Pará · BR

Funding

Unraveling Bacterial Cell Wall Biosynthesis and Sensing via Synthetic AnalogsR35GM124893 · NIGMS · UNIVERSITY OF VIRGINIA · PI Marcos M. Pires · 2017 to 2026
$3.6M
High-speed and high-resolution Zeiss880 multiphoton microscopy systemS10OD025156 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2019 to 2019
$600k
NIGMS NIH HHS R35 GM124893NIH HHS S10 OD025156
6 · The paper itself

Abstract

Bacterial cell walls contain peptidoglycan (PG), a scaffold that provides proper rigidity to resist lysis from internal osmotic pressure and a barrier to protect cells against external stressors. It consists of repeating sugar units with a linkage to a stem peptide that becomes cross-linked by cell wall transpeptidases (TP). While synthetic PG fragments containing l-lysine in the third position on the stem peptide are easier to access, those with

Indexed as

BacteriaCell WallCystineDiaminopimelic AcidMycobacterium smegmatisPeptidoglycanCystineDiaminopimelic AcidPeptidoglycan

Identifiers

PMID33078931
PMCPMC7788745
OpenAlexW3093323082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.