Evidence map›Paper›PMID 33078708›Full record

ArticleeLife2020

3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice.

Lukas Ded, Jae Yeon Hwang, Kiyoshi Miki, Huanan F Shi, Jean-Ju Chung

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
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  3. Molecular basis of the higher-order assembly of CatSper.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. From reservoir to rendezvous: the journey of sperm through the oviduct.Reproduction, fertility, and development · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lukas DedDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, United States.ORCID 0000-0003-1053-4025
Jae Yeon HwangDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, United States.ORCID 0000-0002-6493-4182
Kiyoshi MikiBoston Children's Hospital, Boston, United States.
Huanan F ShiDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, United States.ORCID 0000-0003-3710-5917
Jean-Ju ChungDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, United States.ORCID 0000-0001-8018-1355
Yale University · USBoston Children's Hospital · US

Funding

CatSper regulation of sperm physiology and fertilityR01HD096745 · NICHD · YALE UNIVERSITY · PI Jean-Ju Lucia Chung · 2019 to 2026
$3.4M
Czech Science Foundation GJ20-17403YNICHD NIH HHS R01 HD096745
6 · The paper itself

Abstract

Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca

Indexed as

Acrosome ReactionAnimalsCalcium ChannelsCalcium SignalingFemaleGene Expression RegulationGenitalia, FemaleGlycosylationMaleMiceMolecular ImagingSpermatozoaCalcium ChannelsCatsper1 protein, mousecapacitationCatSpercell biologyfertilizationin situ imagingmolecular biophysicsmolecular heterogeneitymousespermstructural biology

Identifiers

PMID33078708
PMCPMC7707823
OpenAlexW3093297295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.