Evidence map›Paper›PMID 33078701›Full record

ArticleThe American journal of tropical medicine and hygiene2020

Therapeutic Efficacy of Artemether-Lumefantrine for Uncomplicated Falciparum Malaria in Northern Zambia.

Matthew M Ippolito, Julia C Pringle, Mwiche Siame, Ben Katowa, Ozkan Aydemir, Peter O Oluoch, Liusheng Huang, Francesca T Aweeka, Jeffrey A Bailey, Jonathan J Juliano and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Temporal genomic analysis ofmedRxiv : the preprint server for health sciences · 2024
    Article
  9. Malaria in Refugee Children Resettled to a Holoendemic Area of Sub-Saharan Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Matthew M Ippolito1Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Julia C Pringle4W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Mwiche Siame5Ministry of Health, Government of the Republic of Zambia, Lusaka, Zambia.
Ben Katowa6Macha Research Trust, Macha, Zambia.
Ozkan Aydemir7Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
Peter O Oluoch7Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
Liusheng Huang9Department of Clinical Pharmacology, University of California San Francisco School of Pharmacy, San Francisco, California.
Francesca T Aweeka9Department of Clinical Pharmacology, University of California San Francisco School of Pharmacy, San Francisco, California.
Jeffrey A Bailey7Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
Jonathan J Juliano10Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Steven R Meshnick11Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina.
Theresa A Shapiro1Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
William J Moss3The Johns Hopkins Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Philip E Thuma3The Johns Hopkins Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Johns Hopkins University · USBrown University · USGolden Valley Agricultural Research Trust · ZMUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USKenya Medical Research Institute · KEMinistry of Health · ZM

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
TransmissionU19AI089680 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WILLIAM J MOSS · 2010 to 2026
$25.6M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Clinical Pharmacology of Malaria Control and Elimination: Pharmacodynamics ofArtemisinin-based Combination Agents and their Barriers to Drug ResistanceK23AI139343 · NIAID · JOHNS HOPKINS UNIVERSITY · PI IPPOLITO, MATTHEW MICHAEL · 2020 to 2023
$773k
NIAID NIH HHS K23 AI139343NIAID NIH HHS K24 AI134990NIAID NIH HHS P30 AI027763NIAID NIH HHS U19 AI089680
6 · The paper itself

Abstract

Artemether-lumefantrine (AL) is a first-line agent for uncomplicated malaria caused by

Indexed as

AntimalarialsArtemether, Lumefantrine Drug CombinationChild, PreschoolDrug ResistanceFemaleHumansInfantMalaria, FalciparumMaleParasitemiaPlasmodium falciparumZambiaAntimalarialsArtemether, Lumefantrine Drug Combination

Identifiers

PMID33078701
PMCPMC7695049
OpenAlexW3092770001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.