Evidence map›Paper›PMID 33078345›Full record

ReviewTranslational stroke research2021

Aneurysmal Subarachnoid Hemorrhage: the Last Decade.

Sean N Neifert, Emily K Chapman, Michael L Martini, William H Shuman, Alexander J Schupper, Eric K Oermann, J Mocco, R Loch Macdonald

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06288659 (Aneurysmal Subarachnoid Hemorrhage Treatment Based on Intraventricular Intracranial Pressure Monitoring), which is not on this map. Cited by 229 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 10 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06288659 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Aneurysmal Subarachnoid Hemorrhage Treatment Based on Intraventricular Intracranial Pressure Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial

TypeinterventionalSponsorHuashan HospitalRan2024 to 2026Enrolled372ConditionsAneurysmal Subarachnoid Hemorrhage, Intacranial HypertensionArmsIntraventricular intracranial pressure monitoring
3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 10 syntheses or guidelines pooled it, 429 citations in OpenAlex.

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  20. Brain-kidney crosstalk in subarachnoid hemorrhage patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article

169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sean N NeifertDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
Emily K ChapmanDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
Michael L MartiniDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
William H ShumanDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
Alexander J SchupperDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
Eric K OermannDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
J MoccoDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, 10029, USA.
R Loch MacdonaldUniversity Neurosciences Institutes, University of California San Francisco, Fresno Campus, Fresno, CA, 93701-2302, USA. rmacdonald@communitymedical.org.ORCID 0000-0003-4024-8070
Mount Sinai Health System · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) affects six to nine people per 100,000 per year, has a 35% mortality, and leaves many with lasting disabilities, often related to cognitive dysfunction. Clinical decision rules and more sensitive computed tomography (CT) have made the diagnosis of SAH easier, but physicians must maintain a high index of suspicion. The management of these patients is based on a limited number of randomized clinical trials (RCTs). Early repair of the ruptured aneurysm by endovascular coiling or neurosurgical clipping is essential, and coiling is superior to clipping in cases amenable to both treatments. Aneurysm repair prevents rebleeding, leaving the most important prognostic factors for outcome early brain injury from the hemorrhage, which is reflected in the neurologic condition of the patient, and delayed cerebral ischemia (DCI). Observational studies suggest outcomes are better when patients are managed in specialized neurologic intensive care units with inter- or multidisciplinary clinical groups. Medical management aims to minimize early brain injury, cerebral edema, hydrocephalus, increased intracranial pressure (ICP), and medical complications. Management then focuses on preventing, detecting, and treating DCI. Nimodipine is the only pharmacologic treatment that is approved for SAH in most countries, as no other intervention has demonstrated efficacy. In fact, much of SAH management is derived from studies in other patient populations. Therefore, further study of complications, including DCI and other medical complications, is needed to optimize outcomes for this fragile patient population.

Indexed as

Aneurysm, RupturedBrain IschemiaHydrocephalusIntracranial AneurysmSubarachnoid HemorrhageVasospasm, IntracranialHumansDelayed cerebral ischemiaFunctional outcomesMedical complicationsNeurointensive careSubarachnoid hemorrhageVasospasm

Identifiers

PMID33078345
OpenAlexW3093216846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.