Observational studyEuropean journal of pediatrics2021
Predicting nasal high-flow therapy failure by pediatric respiratory rate-oxygenation index and pediatric respiratory rate-oxygenation index variation in children.
Observational study in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Impact of a nurse-driven high-flow nasal cannula weaning protocol on HFNC duration in infants with bronchiolitis: a randomized controlled trial.European journal of pediatrics · 2026Trial
- Development of the Novel FLOX Score to Assess Risk of Intubation in Children With Immunocompromising Conditions Receiving High Flow Nasal Cannula.Pediatric pulmonology · 2026Article
- Article
- Exploratory Analysis of Bedside Variables Associated with Transition Failure in a Selected Cohort of Pediatric Patients Stepped Down from Non-Invasive Ventilation to High-Flow Nasal Cannula After Planned Extubation.Journal of clinical medicine · 2026Article
- Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (respiratory rate-oxygenation index) in predicting failure of high-flow nasal cannula?European journal of pediatrics · 2025Observational
- Respiratory Rate Oxygenation (ROX) index as predictor of high flow nasal cannula in pediatric patients in pediatric intensive care unit.BMC pulmonary medicine · 2024Article
- ROX index as a predictor of failure of high-flow nasal cannula in infants with bronchiolitis.Scientific reports · 2024Article
- Helmet Ventilation in a Child with COVID-19 and Acute Respiratory Distress Syndrome.Case reports in pediatrics · 2024Article
- "Comparative analysis of predictors of failure for high-flow nasal cannula in bronchiolitis".PloS one · 2024Article
- [Analysis of ROX Index, ROX-HR Index, and SpOJournal of Korean Academy of Nursing · 2023Article
- A data-driven model for early prediction of need for invasive mechanical ventilation in pediatric intensive care unit patients.PloS one · 2023Observational
- Predictors of high-flow nasal cannula failure in pediatric patients with acute respiratory distress.Clinical and experimental pediatrics · 2022Article
- Heated Humidified High-Flow Nasal Cannula in Children: State of the Art.Biomedicines · 2022Review
- Analysis of risk factors for the failure of respiratory support with high-flow nasal cannula oxygen therapy in children with acute respiratory dysfunction: A case-control study.Frontiers in pediatrics · 2022Article
- Clinical utility of the pediatric respiratory rate-oxygenation index.European journal of pediatrics · 2021Article
- Reply to: Clinical utility of the pediatric respiratory rate-oxygenation index.European journal of pediatrics · 2021Article
- Predicting Flow Rate Escalation for Pediatric Patients on High Flow Nasal Cannula Using Machine Learning.Frontiers in pediatrics · 2021Article
- High-Flow Nasal Cannula Therapy in Children With Acute Respiratory Distress With Hypoxia in A Pediatric Intensive Care UnitA Single Center Experience.Frontiers in pediatrics · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary objective of this study was to evaluate whether pediatric respiratory rate-oxygenation index (p-ROXI) and variation in p-ROXI (p-ROXV) can serve as objective markers in children with high-flow nasal cannula (HFNC) failure. In this prospective, single-center observational study, all patients who received HFNC therapy in the general pediatrics ward, pediatric intensive care unit, and the pediatric emergency department were included. High-flow nasal cannula success was achieved for 116 (88.5%) patients. At 24 h, if both p-ROXI and p-ROXV values were above the cutoff point (≥ 66.7 and ≥ 24.0, respectively), HFNC failure was 1.9% and 40.6% if both were below their values (p < 0.001). At 48 h of HFNC initiation, if both p-ROXI and p-ROXV values were above the cutoff point (≥ 65.1 and ≥ 24.6, respectively), HFNC failure was 0.0%; if both were below these values, HFNC failure was 100% (p < 0.001).Conclusion: We observed that these parameters can be used as good markers in pediatric clinics to predict the risk of HFNC failure in patients with acute respiratory failure. What is Known: • Optimal timing for transitions between invasive and noninvasive ventilation strategies is of significant importance. • The complexity of data requires an objective marker that can be evaluated quickly and easily at the patient's bedside for predicting HFNC failure in children with acute respiratory failure. What is New: • Our data showed that combining p-ROXI and p-ROXV can be successful in predicting HFNC failure at 24 and 48 h of therapy.
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