ArticleNature neuroscience2020
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
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Who cites it
170 citing papers in PubMed.
- Intermittent Theta Burst Stimulation Improves Sleep in Autism Spectrum Disorder by Reorganizing Overlapping Brain Networks With Neurochemical and Transcriptomic Signatures: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- Thalamic modulation of cortical linearity across arousal states.Science advances · 2026Article
- Dynamic Repertoire of Brain Networks in Mindfulness-Based Cognitive Therapy During Rumination: A Randomized Controlled Trial.Biological psychiatry global open science · 2026Article
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Associations of visceral adipose tissue metabolism with DMN-centered cross-network metabolic expression concordance and cognitive impairment in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2026Article
- Edge-centric brain connectomes reveal two molecularly distinct neurobiological subtypes of adolescent major depressive disorder.European child & adolescent psychiatry · 2026Article
- Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease.Research square · 2026Article
- Dynamic Co-Modulation (DyCoM): A Unified Operator Framework for Dynamic Connectivity in Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- A cortical gradient in area 55b links language and somato-cognitive action networks.Research square · 2026Article
- A Multiscale Spatiotemporal Causal Mapping Algorithm for Revealing Neural Network Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation.Human brain mapping · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- A personalized map of where, when, and how to stimulate the brain to elicit controlled responses.bioRxiv : the preprint server for biology · 2026Article
- Article
- Increasing the Reliability of Functional Connectivity by Predicting Long-Scan Functional Connectivity based on Short-Scan Functional Connectivity: Model Exploration, Explanation, Validation, and Application.Neuroinformatics · 2026Article
- The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction.iScience · 2026Article
- Human striatal population state dynamics.bioRxiv : the preprint server for biology · 2026Article
- Blood-brain barrier integrity and brain entropy in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2026Article
- HESREN: A Derivative-Informed Reservoir Framework for Detecting Transient Neural Events and Windowless Estimation of Dynamic Functional Connectivity.Neuroinformatics · 2026Article
- Oscillatory edge connectivity in pain-related regions supports machine learning identification of migraine.The journal of headache and pain · 2026Article
110 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Network neuroscience has relied on a node-centric network model in which cells, populations and regions are linked to one another via anatomical or functional connections. This model cannot account for interactions of edges with one another. In this study, we developed an edge-centric network model that generates constructs 'edge time series' and 'edge functional connectivity' (eFC). Using network analysis, we show that, at rest, eFC is consistent across datasets and reproducible within the same individual over multiple scan sessions. We demonstrate that clustering eFC yields communities of edges that naturally divide the brain into overlapping clusters, with regions in sensorimotor and attentional networks exhibiting the greatest levels of overlap. We show that eFC is systematically modulated by variation in sensory input. In future work, the edge-centric approach could be useful for identifying novel biomarkers of disease, characterizing individual variation and mapping the architecture of highly resolved neural circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.