ArticleScientific reports2020
Metabolomic and transcriptomic analyses reveal the regulation of pigmentation in the purple variety of Dendrobium officinale.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Integrated Metabolomic and Transcriptomic Analyses Reveal Phenylpropanoid-Associated Variation Among ThreeMetabolites · 2026Article
- Deciphering differentially expressed genes and a flavonoid analysis reveal that the metabolic flux shift of flavonoids lightens flower coloration in γ-irradiation-induced Dendrobium hybrid mutants.BMC plant biology · 2026Article
- Integrated transcriptomic and metabolomic analyses reveal flavonoid and lipid metabolic reprogramming inPeerJ · 2026Article
- Effect of rubusoside, a natural sucrose substitute, on the metabolism of Scardovia wiggsiae: a novel potential cariogenic pathogen.BMC biology · 2025Article
- Application of widely targeted metabolomics strategy to reveal the evolution of phenolic color-contributing metabolites during the high pressure processing and thermal processing of blueberry juice.Food chemistry: X · 2025Article
- Comprehensive Omics Analysis Reveals Cold-Induced Metabolic Reprogramming and Alternative Splicing inPlants (Basel, Switzerland) · 2025Article
- Genome-wide identification and characterization of the GDSL lipase gene family inFrontiers in plant science · 2025Article
- Multi-omics profiling reveal responses of three majorFrontiers in plant science · 2024Article
- Metabolic Pathway Engineering Improves Dendrobine Production inInternational journal of molecular sciences · 2023Article
- Transcriptomic and Metabolomic Analyses Reveal Differences in Flavonoid Pathway Gene Expression Profiles between TwoInternational journal of molecular sciences · 2023Article
- Article
- Transcriptome and metabolome analysis reveals the effect of flavonoids on flower color variation inFrontiers in plant science · 2023Article
- Enhancing the Expression of theInternational journal of molecular sciences · 2022Article
- Article
- Identification of Two GDSL-Type Esterase/Lipase Genes Related to Tissue-Specific Lipolysis inLife (Basel, Switzerland) · 2022Article
- Light and Potassium Improve the Quality ofMolecules (Basel, Switzerland) · 2022Article
- Metabolic Profiling of Terpene Diversity and the Response of Prenylsynthase-Terpene Synthase Genes during Biotic and Abiotic Stresses inInternational journal of molecular sciences · 2022Article
- Response of anthocyanin biosynthesis to light by strand-specific transcriptome and miRNA analysis in Capsicum annuum.BMC plant biology · 2022Article
- DhMYB2 and DhbHLH1 regulates anthocyanin accumulationFrontiers in plant science · 2022Article
- Integration of Transcriptome and Metabolome Provides New Insights to Flavonoids Biosynthesis inFrontiers in plant science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed an integrated analysis of the transcriptome and metabolome from purple (Pr) and normal cultivated varieties (CK) of Dendrobium officinale to gain insights into the regulatory networks associated with phenylpropanoid metabolism and to identify the key regulatory genes of pigmentation. Metabolite and transcript profiling were conducted by ultra-performance liquid chromatography electrospray tandem mass spectrometry (UPLC-ESI-MS/MS) and RNA sequencing. Pr had more flavonoids in the stem than did CK. Metabolome analyses showed that 148 differential metabolites are involved in the biosynthesis of phenylpropanoids, amino acids, purines, and organic acids. Among them, the delphinidin and quercetin derivatives were significantly higher in Pr. A total of 4927 differentially expressed genes (DEGs) were significantly enriched (p ≤ 0.01) in 50 Gene Ontology (GO) terms. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed significantly enriched phenylpropanoid biosynthesis and phytohormone signal transduction in Pr versus CK. The expression levels of flavanone 3-hydroxylase (F3H) and leucoanthocyanidin dioxygenase (LDOX) affected the flux of dihydroflavonol, which led to a color change in Pr. Moreover, DEG enrichment and metabolite analyses reflected flavonoid accumulation in Pr related to brassinosteroid (BR) and auxin metabolism. The results of this study elucidate phenylpropanoid biosynthesis in D. officinale.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.